ABSTRACT
Lymphomas are characterized by a relatively favorable prognosis and a good five-year survival rate, but they are associated with increased psychosocial distress. There is insufficient evidence on the efficacy of psychological interventions for lymphoma patients. This review aimed to present the research findings on currently used psychological interventions for (non-) Hodgkin lymphoma patients and survivors. A literature search on English language peer-reviewed original publications on psychological interventions for lymphoma patients published prior to December 2021 was performed in PubMed, Medline, Web of Science, Scopus and ResearchGate. Titles and abstracts were screened for the relevant terms including psychological intervention and psychological management along with (non-) Hodgkin lymphoma. The retrieved articles were evaluated by independent reviewers, the lists of eligible publications were compared, and disagreements were resolved by discussion. Of the 50 publications sought for retrieval, 8 articles were shortlisted based on their content. The papers were classified according to their content and the methodology employed. Research themes including "promoting resilience in lymphoma survivors", "web-based self-management interventions for patients with lymphoma", "addressing unmet needs whilst undergoing chemotherapy", and "mind-body interactive exercise" were identified and presented in this review. As the number of lymphoma survivors is increasing, future research on evidence-based interventions addressing patients' and survivors' unmet psychological needs is warranted.
Subject(s)
Hodgkin Disease , Humans , Hodgkin Disease/therapy , Survivors/psychologyABSTRACT
BACKGROUND: Systemic sclerosis (SSc) is a multisystemic disease with an extensive microvasculopathy. Previously, disturbances in plasma levels of angiotensin II (Ang II) and its antagonistic angiotensin-(1-7) (Ang-(1-7)) were found in patients with SSc. Their significance in a pathogenesis of SSc stays unclear due to discrepancies of earlier studies. OBJECTIVES: To evaluate a significance of disturbances in production pathway of angiotensins in a development of SSc. METHODS: There were enrolled 27 patients with established SSc, 23 subjects with very early SSc and 23 healthy controls. The diagnosis of SSc was established in patients who met EULAR/ACR 2013 classification criteria. Very early SSc described patients with Raynaud's phenomenon having SSc-specific antinuclear antibodies and SSc-like abnormalities in nailfold videocapillaroscopy. Patients were submitted to evaluation of internal organ involvement and blood sampling to assay plasma levels of angiotensin I, angiotensin II and angiotensin-(1-7) with ELISA technique. RESULTS: Plasma level of angiotensin-(1-7) was significantly reduced in both SSc group (median = 47.2 pg/mL; P < 0.001) and ones with very early SSc (median = 102.7 pg/mL; P = 0.002) when compared to healthy controls (median = 176.1 pg/mL). A tendency to higher than in control group (median = 214 pg/mL) plasma level of angiotensin I was seen in SSc group (median = 392 pg/mL; P = 0.059). Differences in plasma level of angiotensin II were insignificant between all study groups. Those disturbances produced unfavourable angiotensin-(1-7)/angiotensin II (%) ratio in both groups of patients, which achieved statistical significance in subjects with established SSc (P < 0.001). Production pathway of angiotensins showed a dependence on a subtype of SSc, immune profile and a presence of interstitial lung disease. CONCLUSIONS: Production of angiotensin-(1-7) was significantly reduced in both SSc patients and those ones with very early SSc, although a significant imbalance between angiotensin II and angiotensin-(1-7) occurred only in subjects with established disease.
Subject(s)
Angiotensin II/physiology , Angiotensin I/physiology , Peptide Fragments/physiology , Scleroderma, Systemic/etiology , Adult , Aged , Angiotensin I/blood , Angiotensin II/blood , Female , Humans , Male , Middle Aged , Peptide Fragments/blood , Scleroderma, Systemic/blood , Young AdultSubject(s)
Antibodies, Antiphospholipid/drug effects , Antiphospholipid Syndrome/drug therapy , Lupus Erythematosus, Systemic/drug therapy , Simvastatin/therapeutic use , Adult , Antibodies, Antiphospholipid/blood , Female , Humans , Lupus Erythematosus, Systemic/complications , Male , Middle Aged , Simvastatin/administration & dosage , Treatment Outcome , Young AdultSubject(s)
Endothelium, Vascular/drug effects , Heptanoic Acids/therapeutic use , Lupus Erythematosus, Systemic/drug therapy , Pyrroles/therapeutic use , Vasodilation/drug effects , Atorvastatin , Controlled Clinical Trials as Topic , Endothelium, Vascular/physiology , Female , Follow-Up Studies , Humans , Lupus Erythematosus, Systemic/diagnosis , Male , Treatment Outcome , Vasodilation/physiologySubject(s)
Antibodies, Monoclonal/adverse effects , Arthritis, Rheumatoid , Heart Failure/etiology , Tachycardia, Ventricular/etiology , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Arthritis, Rheumatoid/complications , Arthritis, Rheumatoid/drug therapy , Arthritis, Rheumatoid/physiopathology , Contraindications , Female , Heart Failure/physiopathology , Humans , Infliximab , Risk Factors , Tachycardia, Ventricular/physiopathology , Ventricular Dysfunction, Left/etiology , Ventricular Dysfunction, Left/physiopathologySubject(s)
Hypothyroidism/metabolism , Lipids/blood , Scleroderma, Systemic/blood , Thyroid Gland/metabolism , Adult , Case-Control Studies , Cholesterol/blood , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Cohort Studies , Female , Humans , Middle Aged , Physical Examination , Scleroderma, Systemic/classification , Thyrotropin/blood , Thyroxine/blood , Triglycerides/bloodSubject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Cyclooxygenase Inhibitors/therapeutic use , Inflammation/metabolism , Isoenzymes/metabolism , Prostaglandin-Endoperoxide Synthases/metabolism , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Cyclooxygenase 1 , Cyclooxygenase 2 , Cyclooxygenase 2 Inhibitors , Cyclooxygenase Inhibitors/pharmacology , Humans , Isoenzymes/drug effects , Membrane Proteins , Prostaglandin-Endoperoxide Synthases/drug effects , Structure-Activity RelationshipABSTRACT
The interaction of neurotensin and calcium channel modulators is examined in isolated electrically driven guinea pig left atrial appendages. Left guinea pig atria exposed to diltiazem become desensitised to neurotensin. There is no significant influence of verapamil pretreatment on the neurotensin inotropic action. Nifedipine pretreatment causes increase in the inotropic response of guinea pig atria to neurotensin. The regression line of neurotensin after pretreatment with nifedipine compared to the regression line of neurotensin alone has higher slope and is shifted to the left. The ED50 of neurotensin after nifedipine pretreatment compared with the ED50 of neurotensin alone results in potency ratio of 2.24. Bay K8644 significantly decreases the inotropic effect of ED100 of neurotensin. Results suggest that: (1) the mechanism of interaction of calcium channel modulators and neurotensin in the atrium does not depend on the calcium influx through calcium channel nor does it on the calcium channel itself; (2) the interaction of nifedipine and neurotensin is possibly dependent on dihydropyridine receptors, (3) the dihydropyridine binding site, possibly different from voltage-sensitive calcium channel, is somehow involved in the neurotensin action in guinea pig atria.
Subject(s)
Calcium Channel Agonists/pharmacology , Calcium Channel Blockers/pharmacology , Dihydropyridines/pharmacology , Myocardial Contraction/drug effects , Neurotensin/pharmacology , Animals , Calcium Channels/metabolism , Calcium Channels, L-Type , Electric Stimulation , Guinea Pigs , Heart Atria/drug effects , Heart Atria/metabolism , In Vitro Techniques , Male , Myocardium/metabolism , Neurotensin/antagonists & inhibitorsABSTRACT
Case of father and his two sons with multiple osteochondrial exostoses localized on the long bones and impaired joint movements was reported.
Subject(s)
Exostoses, Multiple Hereditary/diagnosis , Adult , Child , Exostoses, Multiple Hereditary/genetics , Humans , MaleABSTRACT
This paper described newly discovered peptides, brain natriuretic peptide and C-type natriuretic peptide. Their structure and metabolism as well as peptides participation to many physiological and pathological states have been reviewed with a special emphasis to their role in blood pressure regulation and mineral and fluid balance.
Subject(s)
Atrial Natriuretic Factor/physiology , Nerve Tissue Proteins/physiology , Proteins/physiology , Amino Acid Sequence , Animals , Atrial Natriuretic Factor/chemistry , Blood Pressure/physiology , Humans , Molecular Sequence Data , Natriuretic Peptide, Brain , Natriuretic Peptide, C-Type , Nerve Tissue Proteins/chemistry , Proteins/chemistry , Water-Electrolyte Balance/physiologyABSTRACT
Toxic effect of insecticide dimethoate applied to 400 rats for two years in concentrations of 2 to 200 mg/kg fodder was investigated. During the last six months of observation the toxic influence of the larger doses of this preparation was manifested by a higher mortality of the animals. Neither disadvantageous influence upon the maturation of each individual haemopoietic series, nor action inducing pathologic proliferation in the haemopoietic system of rats were found.
