Subject(s)
Habenula/drug effects , Neurons/drug effects , Pregnanolone/pharmacology , Animals , Habenula/cytology , Male , Microelectrodes , Neurons/physiology , Pain , Rats , Rats, WistarABSTRACT
AIM: To investigate whether if the Habenula is the main relay involved in the vasopressor effect induced by the stimulus of insular cortex, central-, lateral amygdaloid nucleus respectively. METHODS: Electrostimulation of the nuclei mention above respectively, and microinjection of lidocaine into Habenula unilaterally and bilaterally. RESULTS: When INS or CeA was stimulated, inducing an obvious increase of blood pressure. To stimulate INS or CeA after microinjecting lidocaine into Hb 5 minutes, the amplitudes of the vasopressor responses were decreased significantly, and the decrease of the bilaterally was larger (decreased value: 41.7% in INS, 46.1% in CeA) than that of unilaterally (decreased value: 36.9% in INS, 39.6% in CeA). CONCLUSION: Habenula is one of the main relays involved in the vasopressor effects induced by the stimulus of insular cortex, central-, lateral amygdaloid nucleus.
