1.
Tissue Antigens
; 70(2): 144-50, 2007 Aug.
Article
in English
| MEDLINE
| ID: mdl-17610419
ABSTRACT
Unusual HLA-A'null' alleles because of an entire gene deletion were found in three apparently unrelated Japanese families with leukemia patients. Inclusion of the entire HLA-A gene in the deletion was confirmed by polymerase chain reaction direct sequencing of the surrounding regions of HLA-A. Further localization of the breakpoints of the HLA-A deletion at the centromeric and telomeric sides was performed, and these families were shown to possess the identical deletion. We then determined the genomic sequence of the HLA-A-deleted haplotype. Surprisingly, the haplotype turned out to carry an insertion of an SVA (SINE-VNTR-Alu) retrotransposon of 2 kb as well as the 14 kb deletion that included the entire HLA-A gene.
Subject(s)
Gene Deletion , HLA-A Antigens/genetics , Retroelements/genetics , Female , Haplotypes/genetics , Humans , Male , Pedigree
2.
Chem Pharm Bull (Tokyo)
; 21(2): 404-14, 1973 Feb.
Article
in English
| MEDLINE
| ID: mdl-4753311