ABSTRACT
BACKGROUND: The role of laparoscopic treatment in acute appendicitis still is unclear. Although some evidence in the literature suggests diagnostic benefits from laparoscopy for young women with suspected acute appendicitis, there is scepticism about the utility of this approach for men. This study aimed to compare open and laparoscopic appendectomy performed for men with suspected acute appendicitis. METHODS: All male patients older than 15 years with an American Society of Anesthesiology (ASA) classification of 3 or less, no previous abdominal surgery, and no contraindication for pneumoperitoneum were prospectively randomized to undergo either open appendectomy (OA) or laparoscopic appendectomy (LA). The primary end point was a detected difference in postoperative hospital length of stay, and the secondary end points were detected differences in postoperative analgesia, morbidity, and length of the recovery period. RESULTS: In this study, 147 men with suspected acute appendicitis were randomized to either OA (n = 75) or LA (n = 72). It took longer to perform LA (60 min; range, 20-120 min vs. 45 min; range, 20-90 min; p = 0.0027), and LA did not result in any significant difference for the parameters evaluated. CONCLUSION: The postoperative length of hospital stay did not differ significantly between OA and LA for men. Laparoscopic appendectomy required more time and did not offer any advantages compared with OA.
Subject(s)
Appendectomy/methods , Appendicitis/surgery , Laparoscopy , Adolescent , Adult , Aged , Humans , Male , Middle Aged , Prospective Studies , Young AdultABSTRACT
The aim of the study was to investigate if human pleura from different anatomical locations presents electrophysiology differences. Specimens were stripped over the 2nd-5th rib (cranial), 8th-10th rib (caudal), and mediastinum during open surgery and were mounted between Ussing chambers. Amiloride and ouabain were added towards mesothelial surface and trans-mesothelial potential difference (PD) was measured after 1, 5, 10 and 20 min. Trans-membrane resistance (R) was calculated from Ohm's law. R increased after amiloride addition, for cranial (net increase of 0.40 Omega x cm(2)) and caudal (1.16 Omega x cm(2)) pleural pieces. Mediastinal pleura R remained unchanged (0.09 Omega x cm(2)). R increase was higher for caudal than cranial (P=0.029) or mediastinal tissues (P=0.002). R increased after ouabain addition for caudal (1.35 Omega x cm(2)) and cranial (0.56 Omega x cm(2)) pleural pieces. Mediastinal pleural tissue did not respond (0.20 Omega x cm(2)). Caudally located pleura responded greater than cranial (P=0.043) or mediastinal (P=0.003) pleural tissues. Human pleura shows electrophysiology differences according to the location within the pleural cavity. Surgeons may waste mediastinal pleura when needed but should leave intact caudal parietal pleura, which seems to be electrophysiologically the most important part of the pleural cavity.
Subject(s)
Epithelium/metabolism , Pleura/metabolism , Amiloride/pharmacology , Electric Impedance , Enzyme Inhibitors/pharmacology , Epithelium/drug effects , Epithelium/enzymology , Epithelium/surgery , Humans , Mediastinum , Membrane Potentials , Ouabain/pharmacology , Permeability , Pleura/drug effects , Pleura/enzymology , Pleura/surgery , Pleural Cavity , Ribs , Sodium Channel Blockers/pharmacology , Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors , Sodium-Potassium-Exchanging ATPase/metabolismABSTRACT
We report the case of a 56-y-old male admitted with a left-sided post-pneumonic empyema. Clostridium sordellii DNA was directly detected in its pleural fluid by a broad-range 16S rRNA PCR, after 24 h of specimen collection. This is the third case of pleural infection caused by C. sordellii in the literature.
