ABSTRACT
Introduction: Poor sleep quality have been widely reported in patients with long COVID. Determining the characteristics, type, severity, and relationship of long COVID with other neurological symptoms is essential for the prognosis and management of poor sleep quality. Methods: This cross-sectional study was conducted at a public university in the eastern Amazon region of Brazil between November 2020 and October 2022. The study involved 288 patients with long COVID with self-report neurological symptoms. One hundred thirty-one patients were evaluated by using standardised protocols: Pittsburgh sleep quality index (PSQI), Beck Anxiety Inventory, Chemosensory Clinical Research Center (CCRC), and Montreal Cognitive Assessment (MoCA). This study aimed to describe the sociodemographic and clinical characteristics of patients with long COVID with poor sleep quality and their relationship with other neurological symptoms (anxiety, cognitive impairment, and olfactory disorder). Results: Patients with poor sleep quality were mainly women (76.3%), 44.04 ± 12.73 years old, with >12 years of education (93.1%), and had monthly incomes of up to US $240.00 (54.2%). Anxiety and olfactory disorder were more common in patients with poor sleep quality. Discussion: Multivariate analysis shows that the prevalence of poor sleep quality was higher in patients with anxiety, and olfactory disorder is associated with poor sleep quality. In this cohort of patients with long COVID, the prevalence of poor sleep quality was highest in the group tested by PSQI and were associated with other neurological symptoms, such as anxiety and olfactory dysfunction. A previous study indicates a significant association between poor sleep quality and psychological disorders over time. Recent studies involving neuroimaging found functional and structural changes in Long COVID patients with persistent olfactory disfunction. Poor sleep quality are integral part of complex changes related to Long COVID and should be part of patient's clinical management.
ABSTRACT
Objetivo: Caracterizar o perfil clínico e epidemiológico dos pacientes com câncer de cabeça e pescoço atendidos em um hospital universitário. Métodos: Estudo epidemiológico descritivo e retrospectivo de todos os casos de câncer de cabeça e pescoço diagnosticados no período de agosto de 2009 a agosto de 2014 no setor de Otorrinolaringologia do Hospital Universitário Bettina Ferro de Sousa da Universidade Federal do Pará. Resultados: Dos 81 pacientes selecionados, 88,1% apresentaram carcinoma epidermoide como tipo histológico. A média de idade foi de 60,6 anos e 67% deles se declararam fumantes com tempo médio de 30 anos de tabagismo. Os sintomas mais relatados foram dor local (42%), seguida por disfonia (39%). A localização foi predominantemente laríngea em 35 pacientes (46%), seguida por câncer de boca em 15 (19,7%) pacientes e faringe em 13 (17,1%). Houve predomínio do sexo masculino e idade a partir da quinta década de vida. Conclusão: O tipo histológico predominante de carcinoma epidermoide e a forte associação desses tumores com o tabagismo estiveram de acordo com outros trabalhos sobre o câncer de cabeça e pescoço. A alta incidência de disfonia se deu pela predominância da localização laríngea. Exceto pela predominância de localização laríngea em detrimento das lesões de boca, o presente trabalho se mostra de acordo com os dados da literatura brasileira quanto aos aspectos clínicos e epidemiológicos do câncer de cabeça e pescoço.
Objective: To characterize the clinico-epidemiological profile of patients with head and neck cancer treated in a university hospital. Methods: descriptive and retrospective epidemiological study of all cases of head and neck câncer diagnosed in the period of August 2009 to August 2014 in the Otorhinolaryngology department of Hospital Universitário Bettina Ferro de Sousa in Universidade Federal do Pará. Results: Of the 81 patients selected, 88.1% had squamous cell carcinoma as histological type. The mean age was 60.6 years, and 67% of them reported being smokers for an average of 30 years of smoking. The most reported symptoms were local pain (42%), followed by dysphonia (39%). The location was predominantly laryngeal in 35 patients (46%), followed by oral cancer in 15 (19.7%), and pharyngeal in 13 (17.1%) patients. There was a predominance of male gender, and age from the fifth decade of life. Conclusion: The predominant histological type of squamous cell carcinoma and the strong association of these tumors with smoking are consistent with other works on head and neck cancer. The high incidence of dysphonia was due to the prevalence of laryngeal location. This study showed to be in accordance with data from the Brazilian literature regarding the clinical and epidemiological aspects of head and neck cancer, except for the predominance of laryngeal location over mouth lesions.
