ABSTRACT
Recent rapid development of cancer therapy has come about with the paradigm shift from the traditional goal of targeting cancer cells themselves, to reprograming the immune tumor microenvironment. Accumulating evidence shows that compounds that target epigenetic regulation, called epidrugs, play a crucial role in mediating the immunogenicity of cancer cells and in reshaping antitumor immunity. A large body of literature has recognized natural compounds as epigenetic modulators for their immunomodulatory effects and anticancer potential. Unifying our understanding of the role of these biologically active compounds in immuno-oncology may open new avenues for more effective cancer therapies. In this review, we explore how natural compounds modulate the epigenetic machinery to shape antitumor immune response, highlighting the promise offered by the Mother Nature that could be exploited therapeutically to improve outcomes for cancer patients.
Subject(s)
Epigenesis, Genetic , Neoplasms , Humans , Immunotherapy , Neoplasms/drug therapy , Neoplasms/genetics , Tumor MicroenvironmentABSTRACT
Cancer immunotherapy has made breakthrough progress in cancer treatment. However, only a subset of patients benefits from immunotherapy. Given their unique structure, composition, and interactions with the immune system, carbon nanomaterials have recently attracted tremendous interest in their roles as modulators of antitumor immunity. Here, we focused on the latest advances in the immunological effects of carbon nanomaterials. We also reviewed the current preclinical applications of these materials in cancer therapy. Finally, we discussed the challenges to be overcome before the full potential of carbon nanomaterials can be utilized in cancer therapies to ultimately improve patient outcomes.
Subject(s)
Nanostructures , Neoplasms , Humans , Carbon/therapeutic use , Carbon/chemistry , Neoplasms/therapy , Nanostructures/therapeutic use , Nanostructures/chemistry , Immunotherapy , Medical OncologyABSTRACT
Epigenetic remodeling and metabolic reprogramming, two well-known cancer hallmarks, are highly intertwined. In addition to their abilities to confer cancer cell growth advantage, these alterations play a critical role in dynamically shaping the tumor microenvironment and antitumor immunity. Recent studies point toward the interplay between epigenetic regulation and metabolic rewiring as a potentially targetable Achilles' heel in cancer. In this review, we explore the key metabolic mechanisms that underpin the immunomodulatory role of AT-rich interaction domain 1A (ARID1A), the most frequently mutated epigenetic regulator across human cancers. We will summarize the recent advances in targeting ARID1A-deficient cancers by harnessing immune-metabolic vulnerability elicited by ARID1A deficiency to stimulate antitumor immune response, and ultimately, to improve patient outcome.
Subject(s)
Neoplasms , Transcription Factors , Humans , DNA-Binding Proteins/metabolism , Epigenesis, Genetic , Neoplasms/genetics , Neoplasms/immunology , Neoplasms/therapy , Nuclear Proteins/metabolism , Transcription Factors/metabolism , Tumor MicroenvironmentABSTRACT
Cancer is the second leading cause of death all around the world. The natural compounds derived from the endophytic flora of fungi are possible solutions to cancer treatment because they are safe for health, cost-effective, biocompatible and have fewer toxicity issues. The active ingredients in endophytic fungi that are responsible for anti-cancer activities are alkaloids, terpenoids, glycosides, saponin, peptides, steroids, phenols, quinones, and flavonoids. This review highlights the anti-cancer activities of entophytic fungus against human papillary thyroid carcinoma (IHH4), human pancreatic (PANC-1), ovarian (OVCAR-3), hepatic (HepG2), lung (A-549), human lymphoma (U937), human skin carcinoma (A431), breast (MCF-7), and Kaposi's sarcoma. The emerging evidence suggested that bioactive compounds isolated from endophytic fungi showed their anti-cancer activities by revealing the disturbance of the microtubule network caused by increased levels of Bax and Bcl-2 proteins that triggers cell cycle arrest at the G2-M phase, by inhibiting the DNA replication via binding with topoisomerase II, by regulating the activity of extracellular signal-regulated kinase and NF-kB, by evaluating the levels of p21, p27, and cyclins B/D1/E that led to cell death by apoptosis and cell cycle arrest. This review will assist readers in better comprehending bioactive chemicals and the beneficial interaction between the fungal endophytes and medicinal plants.
ABSTRACT
Objective To evaluate the knowledge and attitude of undergraduate medical students of Poonch Medical College about blood donation. Methods This cross-sectional study was done using a 27-item, validated, interviewer-administered questionnaire involving undergraduate medical students from March to October 2018. Informed consent and ethical clearance were secured. Results A total of 318 undergraduate medical students (response rate of 63.6%) was included in this study. Most respondents knew the difference between whole blood and blood components (294; 92.5%) and they also believed that spreading knowledge of blood donation among the health workers is a necessity (306; 96.2%). There was a statistically significant correlation between knowledge and attitude (p .021). Overall knowledge was higher among the female students (p = .019). Conclusion The study revealed an overall good level of knowledge and attitude among medical students. However, there are still areas of improvement such as blood donation and vaccination-related knowledge. The study also identified important facilitators and barriers to blood donation.
