Subject(s)
Drug Eruptions , Exanthema , Hematologic Neoplasms , Disease Progression , Hematologic Neoplasms/diagnosis , HumansABSTRACT
Lichen planus is a chronic inflammatory, immunologically mediated mucocutaneous dermatosis. Lichen planus mucosae predominantly affects the oral cavity. Various trigger factors such as bacterial or viral infections, drugs or physical stimuli are discussed in the development of the disease. An association with human papillomavirus infections has also been described, but is not sufficiently proven. Lichen planus mucosae is considered as a premalignant condition, but the malignant transformation rate is low. The risk of malignant transformation is significantly increased in patients with oral lichen planus who smoke, drink alcohol or have hepatitis C. We describe two patients with locally advanced squamous cell carcinoma that developed on a longstanding oral lichen planus. Both cases were successfully treated with radical tumor resection, subsequent tissue reconstruction, and adjuvant radiation/radiochemotherapy.
Subject(s)
Carcinoma, Squamous Cell , Lichen Planus, Oral , Lichen Planus , Mouth Neoplasms , Precancerous Conditions , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/therapy , Humans , Lichen Planus/diagnosis , Lichen Planus, Oral/diagnosis , Precancerous Conditions/diagnosisSubject(s)
Alphapapillomavirus , Rothmund-Thomson Syndrome , Administration, Cutaneous , Humans , Papillomaviridae , SkinSubject(s)
Bendamustine Hydrochloride/administration & dosage , Debridement , Intraepithelial Lymphocytes/pathology , Lymphoma, T-Cell, Cutaneous/therapy , Skin/pathology , Administration, Cutaneous , Biopsy , Chemotherapy, Adjuvant/methods , Drug Administration Schedule , Humans , Lymphoma, T-Cell, Cutaneous/complications , Lymphoma, T-Cell, Cutaneous/diagnosis , Lymphoma, T-Cell, Cutaneous/pathology , Magnetic Resonance Imaging , Male , Middle Aged , Necrosis/diagnosis , Necrosis/etiology , Necrosis/pathology , Necrosis/therapy , Neoplasm Staging , Receptors, Antigen, T-Cell, gamma-delta/analysis , Receptors, Antigen, T-Cell, gamma-delta/metabolism , Skin/diagnostic imaging , Treatment OutcomeSubject(s)
Foot/pathology , Sarcoma, Kaposi , Skin/pathology , Aged, 80 and over , Herpesvirus 8, Human , Humans , MaleSubject(s)
Granuloma/pathology , Heel/pathology , Hemorrhage/etiology , Sarcoma, Kaposi/pathology , Skin Neoplasms/pathology , Aged , Female , HumansABSTRACT
is missing (Short communication).
Subject(s)
Carcinoma in Situ/virology , Carcinoma, Squamous Cell/virology , Human papillomavirus 16/isolation & purification , Papillomavirus Infections/virology , Skin Neoplasms/virology , Adult , Aged , Biomarkers, Tumor/analysis , Carcinoma in Situ/chemistry , Carcinoma in Situ/pathology , Carcinoma in Situ/surgery , Carcinoma, Squamous Cell/chemistry , Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Cyclin-Dependent Kinase Inhibitor p16/analysis , Female , Human Papillomavirus DNA Tests , Human papillomavirus 16/genetics , Humans , Immunohistochemistry , Papillomavirus Infections/pathology , Papillomavirus Infections/surgery , Skin Neoplasms/chemistry , Skin Neoplasms/pathology , Skin Neoplasms/surgery , Skin Transplantation , Toes , Treatment OutcomeABSTRACT
An atypical variant of hand-foot-mouth disease (HFMD) has sporadically been reported in recent years, with outbreaks in Europe, Asia, the USA and South America. A new lineage of Coxsackie virus A6 has been identified as the causative agent, a virus-type belonging to the group of enteroviruses. HFMD is transmitted through droplet infection or through faecal-oral transmission. The disease may begin with a prodromal stage and is often accompanied by fever and malaise. Typical skin findings include a papular and vesiculobullous exanthema that might be accompanied by confluent blisters (bullae), crusting, and ulceration. In contrast to "classic" HFMD, predilection sites include the dorsal aspects of the hands and feet, forearms, lower legs, neck and trunk. Oral lesions may be present, but are less often seen compared to "classic" HFMD. The course of the disease is self-limiting, with complete resolution usually within 7-14 days after disease onset. The treatment of atypical HFMD is usually symptomatic. A diagnosis of atypical HFMD might be challenging due to the polymorphous presentation of the disease. This review describes a rarely reported but more frequently diagnosed viral condition.
