ABSTRACT
A 58-year-old man presented with spinal cord compression due to a metastatic liposarcoma of the thoracic spine. There was no evidence of vertebral bone involvement radiographically. This rare case is presented and its clinical features and diagnosis are discussed.
Subject(s)
Epidural Neoplasms/secondary , Liposarcoma, Myxoid/secondary , Muscle Neoplasms/pathology , Epidural Neoplasms/complications , Epidural Neoplasms/pathology , Humans , Leg , Liposarcoma, Myxoid/complications , Liposarcoma, Myxoid/pathology , Male , Middle Aged , Spinal Cord Compression/etiologyABSTRACT
This study compares the healing of lesions made in the occipital region of the calvarium of 5 foetal and 4 post-natal lambs. The foetuses, operated on between the 83rd and 91st day of gestation, had a bone flap elevated and the post-natal lambs, aged about 6 weeks, had a craniectomy and replacement of the bone pieces. The foetuses were delivered spontaneously at full-term. All the animals had computed tomographic (CT) scans and, after sacrifice, naked eye examination of the bony lesions. These showed that there was poor ossification of the lesions made in the foetuses compared to those made in the post-natal lambs. These findings need to be taken into account when intra-uterine correction of cranio-facial deformities are being contemplated.
Subject(s)
Skull/injuries , Wound Healing/physiology , Age Factors , Physical Examination/methods , Skull/diagnostic imaging , Skull/embryology , Tomography, X-Ray ComputedABSTRACT
We have studied formalin fixed, paraffin-wax embedded tissue from 35 medulloblastomas, collected over 23 years (27 non-desmoplastic and 8 desmoplastic) with KP1 and Mac387 two monoclonal anti-monocytes/macrophage (M/Ms) antibodies recommended for use on paraffin wax embedded tissue. In non-desmoplastic medulloblastomas, outside areas of necrosis, M/Ms were detected in 50% of cases with KP1 and 52% with Mac387. M/Ms were seen in 100% of desmoplastic medulloblastomas with both antibodies. Semiquantitative assessment revealed that, on average, desmoplastic tumors had at least three times as many infiltrating M/Ms as non-desmoplastic tumors. There was no significant difference in the findings with the two antibodies or, between recently embedded and "older" tumors. The findings may be indicative of the presence of a host M/Ms immune response in medulloblastoma, which may be more accentuated in desmoplastic medulloblastomas. Furthermore, we conclude that these antibodies are quite suitable for the study of infiltrating M/Ms, thus lessening (but not obviating) the need for frozen tissue for immunohistological studies.