1.
Farmaco
; 54(10): 678-83, 1999 Oct 30.
Article
in English
| MEDLINE
| ID: mdl-10575737
ABSTRACT
The study of the relative binding affinity of a set of 2,3-disubstituted indenes to the receptors of steroid hormones indicates a weak effect of some derivatives on estrogen, progesterone and androgen receptors. The antiproliferative effect on human MCF-7 cells also shows a weak activity for three derivatives.
Subject(s)
Antineoplastic Agents/chemical synthesis , Indenes/chemical synthesis , Receptors, Steroid/metabolism , Antineoplastic Agents/metabolism , Antineoplastic Agents/pharmacology , Breast Neoplasms/drug therapy , Breast Neoplasms/pathology , Female , Humans , Indenes/metabolism , Indenes/pharmacology , Structure-Activity Relationship , Tumor Cells, Cultured
2.
Ann Pharm Fr
; 48(1): 32-7, 1990.
Article
in French
| MEDLINE
| ID: mdl-2082799
ABSTRACT
The synthesis and the study of the cardiovascular and antiallergic properties of 2-(4-dialkylaminoalkoxybenzylidene)-benzo-[b]-1-cyclanones analogues to benzarone and amiodarone were performed. They showed the influence of the length of the basic dialkylaminoalkoxy group and that of a methoxy substitutant of the tetralone on the studied activities.
