ABSTRACT
BACKGROUND: The brain-derived neurotrophic factor (BDNF) is a key protein in maintaining neuronal integrity. The BDNF gene is thought to play an important role in the pathophysiology of mood and anxiety disorders. The aim of this study was to investigate, for the first time in a single study, the association between BDNF Val(66)Met polymorphism, anxiety, alcohol consumption, and cortisol stress response. METHOD: 98 healthy university students (54 females and 44 males), genotyped for the Val(66)Met polymorphism, participated in a physical-stress procedure (cold pressure test, CPT) after having been informed that they would undergo a painful experience. Indices of anxiety and of stress were collected from repeated measurement of salivary cortisol, blood pressure, and heart rate. RESULTS: BDNF Met carriers, were more anxious during the CPT (p<0.001), drank more alcohol per week, (p<0.05), and showed significantly higher anticipatory cortisol response (p<0.05), but not in response to the CPT, than Val/Val homozygotes. The association of BDNF Val(66)Met polymorphism with HPA axis reactivity to stress was not modulated by gender. These results suggest that Met carriers are particularly sensitive in anticipating stressful events, which extends previous findings on the moderating role of the BDNF Val(66)Met polymorphism in the face of stressful life events.
Subject(s)
Alcohol Drinking/genetics , Anticipation, Psychological/physiology , Anxiety/genetics , Brain-Derived Neurotrophic Factor/genetics , Hydrocortisone/metabolism , Polymorphism, Single Nucleotide , Stress, Psychological/genetics , Adolescent , Adult , Alcohol Drinking/metabolism , Amino Acid Substitution/genetics , Anxiety/metabolism , Anxiety/psychology , Female , Health , Humans , Life Change Events , Male , Methionine/genetics , Sex Factors , Stress, Psychological/metabolism , Stress, Psychological/psychology , Valine/genetics , Young AdultABSTRACT
Goal preferences indicate intentions to achieve or avoid particular states. We examined whether Curacaoan and Dutch students differ in goal preferences related to school and whether goal preferences are associated with students' evaluation of the classroom climate. Measurement invariance of the instruments was also tested between samples. Participants attended vocational high schools in Curacao (N = 276) or in the Netherlands (N = 283). Both the classroom climate and goal preferences differed between the samples. In the Netherlands the preference for individuality, belongingness, and recognition was stronger, whereas in Curacao mastery, satisfaction, self-determination, and material gain were more frequently endorsed. The two variables were modestly correlated. Schools do have a globalizing effect on students' school experiences and hardly adapt to goal preferences. The latter seem to be affected by non-school related cultural factors.
