The modified vaccination technique designed to prevent and cure acute and chronic disorders.

In spite of enormous efforts there have been no solutions to date for preventing/terminating certain acute and chronic disorders of humans by vaccination or drugs. Yet it is well understood that if the target antigen (ag) could be presented appropriately to the cells of the immune system then solutions could be found. Recently, the Barabas research group has introduced and described the third vaccination method - called modified vaccination technique (MVT) - which has the ability to provide a corrective immune response in experimental animals with an autoimmune kidney disease. Injections of immune complexes - made up of the target ag and specific non-pathogenic IgM antibodies directed against the target ag - achieved downregulation of pathogenic immune responses and tolerance to self was regained. Utilizing the immune system's natural abilities to respond to corrective information, the MVT technique was able to prevent an autoimmune kidney disease from occurring (prophylactic effect) in experimental animals, and when present, terminating it (therapeutic effect) specifically and without measurable side effects.It is predicted that the application of the MVT will have the potential in the future to revolutionize the preventative and therapeutic options for dealing with chronic disorders in humans (such as autoimmune disease, cancer and acute chronic infections) and achieve cures.

Embracing the Future Internet of Things.

All of the objects in the real world are envisioned to be connected and/or represented, through an infrastructure layer, in the virtual world of the Internet, becoming Things with status information. Services are then using the available data from this Internet-of-Things (IoT) for various social and economical benefits which explain its extreme broad usage in very heterogeneous fields. Domain administrations of diverse areas of application developed and deployed their own IoT systems and services following disparate standards and architecture approaches that created a fragmentation of things, infrastructures and services in vertical IoT silos. Coordination and cooperation among IoT systems are the keys to build "smarter" IoT services boosting the benefits magnitude. This article analyses the technical trends of the future IoT world based on the current limitations of the IoT systems and the capability requirements. We propose a hyper-connected IoT framework in which "things" are connected to multiple interdependent services and describe how this framework enables the development of future applications. Moreover, we discuss the major limitations in today's IoT and highlight the required capabilities in the future. We illustrate this global vision with the help of two concrete instances of the hyper-connected IoT in smart cities and autonomous driving scenarios. Finally, we analyse the trends in the number of connected "things" and point out open issues and future challenges. The proposed hyper-connected IoT framework is meant to scale the benefits of IoT from local to global.

The Modified Vaccination Technique.

In addition to active and passive immunizations, there is a third method of immunization, the modified vaccination technique, which is based on injecting a combination of target antigens and antibodies against this antigen. The vaccine is essentially comprised of immune complexes with pre-determined immune-inducing components. When such an immune complex (target antigen × antibody against the target antigen) with a slight antigen excess is administered, it evokes a corrective immune response by the production of the same antibody with the same specificity against the target antigen that is present in the immune complex (pre-determined immune response).