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3.
Antibiot Med Biotekhnol ; 30(2): 115-8, 1985 Feb.
Article in Russian | MEDLINE | ID: mdl-4039911

ABSTRACT

The experiments with male albino rats showed that in toxic doses tetracycline induced affections of the liver evident from activation of transferases and alkaline phosphatases in the blood serum, inhibition of bile secretion, synthesis and secretion of bile acids and excretion of bilirubin and cholesterol with the bile. Moreover, the content of the products of lipid peroxidation in liver homogenates increased. Acute intoxication with ethyl alcohol also induced hepatic disorders. However, they were less pronounced. The intoxication was accompanied by inhibition of cholopoiesis associated with increasing free radical oxidation of lipids. On combined use of tetracycline and ethyl alcohol no potentiation or summation of their hepatotoxicity was observed.


Subject(s)
Alcoholic Intoxication/metabolism , Bile/metabolism , Chemical and Drug Induced Liver Injury/metabolism , Lipid Peroxides/metabolism , Liver/metabolism , Animals , Bile Acids and Salts/metabolism , Bilirubin/metabolism , Chemical and Drug Induced Liver Injury/etiology , Cholesterol/metabolism , Free Radicals , Humans , Male , Rats , Tetracycline/toxicity
9.
Vopr Onkol ; 25(3): 28-30, 1979.
Article in Russian | MEDLINE | ID: mdl-107650

ABSTRACT

Under observation were 175 patients with ovarian tumors and cysts. The distribution of ABO blood groups and Rh factor in relation to this pathology was studied as compared with the control series (2000 healthy females). There was noted an increased probability of the incidence of the majority of the ovarian tumor types among AB blood group females compared with other groups (O, A and B), and just the opposite, the probability of the tumoriform processes incidence in AB group females is considerably less than in other groups. The probability of ovarian tumors malignification proved to be the least in B group females. There is noted a considerably increased relative ovarian tumor and cyst morbidity among Rh-positive females compared with Rh-negative ones.


Subject(s)
ABO Blood-Group System , Ovarian Cysts/blood , Ovarian Neoplasms/blood , Rh-Hr Blood-Group System , Female , Humans , Isoantigens/analysis , Ovarian Cysts/immunology , Ovarian Neoplasms/immunology , Probability
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