[The interactions along the microbiota-gut-brain axis in the regulation of circadian rhythms, sleep mechanisms and disorders]. / Rol' vzaimosvyazei po osi mozg­kishechnik­mikrobiom v regulyatsii tsirkadiannykh ritmov, mekhanizmakh sna i ikh narushenii.

The bidirectional relationship between cerebral structures and the gastrointestinal tract involving the microbiota embraces the scientific concept of the microbiota-gut-brain axis. The gut microbiome plays an important role in many physiological and biochemical processes of the human body, in the immune response and maintenance of homeostasis, as well as in the regulation of circadian rhythms. There is a relationship between the higher prevalence of a number of neurological disorders, sleep disorders and changes in the intestinal microbiota, which actualizes the study of the complex mechanisms of such correlation for the development of new treatment and prevention strategies. Environmental factors associated with excessive light exposure can aggravate the gut dysbiosis of intestinal microflora, and as a result, lead to sleep disturbances. This review examines the integrative mechanisms of sleep regulation associated with the gut microbiota (the role of neurotransmitters, short-chain fatty acids, unconjugated bile acids, bacterial cell wall components, cytokines). Taking into account the influence of gut dysbiosis as a risk factor in the development of various diseases, the authors systematize key aspects and modern scientific data on the importance of microflora balance to ensure optimal interaction along the microbiota-gut-brain axis in the context of the regulatory role of the sleep-wake cycle and its disorders.

[Russian Medical Academy of Continuing Professional Education - the leading educational institution in the country for the training of forensic medical personnel (for the 90th anniversary from the establishment of the department of forensic medicine)]. / Rossiiskaya meditsinskaya akademiya nepreryvnogo professional'nogo obrazovaniya ­ vedushchee obrazovatel'noe uchrezhdenie strany po podgotovke sudebno-meditsinskikh kadrov (k 90-letiyu so dnya obrazovaniya kafedry sudebnoi meditsiny).

The article presents a detailed analysis of the stages of formation, development and achievements of the forensic medicine department of the Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, established in 1933 yr. More than 100 resident doctors and 15 PhD students have been trained in the department for 90 years. As a part of additional professional education implementation, more than 800 cycles of training courses for forensic medical and forensic experts and more than 30 cycles of professional retraining for doctors of other specialties have been carried out. More than 160 thous. specialists have been trained at the department since its establishment. Many employees of the department were directly involved in the performance of the most complicated and socially significant forensic medical examinations. The article describes the main achievements and scientific directions of the department's staff activity, directions and prospects of improving the training of forensic medical personnel in the country.

[Features of detection and interpretation of intravital and postmortem changes according to the results of traditional X-ray and X-ray computed tomography of objects from historical graves and artefacts]. / Osobennosti vyyavleniya i interpretatsii prizhiznennykh i posmertnykh izmenenii po rezul'tatam traditsionnoi rentgenografii i rentgenovskoi komp'yuternoi tomografii ob"ektov iz istoricheskikh zakhoronenii i artefaktov.

OBJECTIVE: To study emergence mechanism, physical nature, pattern of intravital and postmortem changes of biological and non-biological objects originated in the period from 1550 to 1918 yr. using traditional X-ray and X-ray computed tomography. MATERIAL AND METHODS: The relics of Saint Macarius the Roman of Novgorod, the remains of the First Reverend of the Resurrection Novodevichy Convent in Saint Petersburg Mother Superior Theophania, damages on the chair leg on which Tsesarevich Alexey sat during the shooting of Russian Emperor Nicholas II, his family and entourage in 1918 in Yekaterinburg were stidued. RESULTS AND CONCLUSION: The application of highly informative methods of traditional X-ray and X-ray computed tomography of biological and non-biological objects showed their high informativity and allowed to correctly interpret the emergence mechanism, physical nature, pattern of intravital and postmortem changes of skeleton bones and historical artefact (chair legs) originated long ago. The necessity of special professional training and advanced training of experts in forensic radiology to prevent possible diagnostic and expert errors has been substantiated.

[Conceptual approaches to defining the one-pointedness of forensic expert institutions as a factor determining the effectiveness of their interaction]. / Kontseptual'nye podkhody k opredeleniyu odnoprofil'nosti sudebno-ekspertnykh uchrezhdenii kak faktor, opredelyayushchii effektivnost' ikh vzaimodeistviya.

THE OBJECTIVE OF THE STUDY: Is to identify the effectiveness of cooperation between forensic expert institutions on the basis of approaches to determining their one-pointedness. Legislative and regulatory legal acts regulating forensic expert activity have been studied. Methods of synthesis, analysis and comparison have been used for their processing. The comparison of the carrying out of targeted diversified studies has been conducted. The article substantiates a necessity of uniform approaches to determination of one-pointedness of forensic expert institutions in order to increase the effectiveness of interdepartmental interaction.

[Fatal radiation-induced injury resulting from the deliberate use of ionizing radiation source for illegal purposes]. / Smertel'naya radiatsionnaya travma vsledstvie umyshlennogo primeneniya istochnika ioniziruyushchego izlucheniya v protivopravnykh tselyakh.

A rare clinical observation of death from prolonged uneven external irradiation due to the deliberate use of an ionizing radiation source for illegal purposes has been presented. The main difficulties of postmortem diagnosis of this type of radiation-induced injury, considering the features of histological examinations and special methods of retrospective dosimetric evaluations, have been identified.

[The scientific conceptions of disability in the Soviet state in the 1930s].

The article analyzes development of scientific conceptions of disability in works of Soviet researchers during the period of forced construction of socialism. The materials of the dissertation abstract of employee of the North Caucasian Scientific and Research Institute of Labor Organization and Protection (1933), as well as publications of staff of the Leningrad Scientific and Research Institute of Medical and Labor Expertise and Professional Consultation (1935-1940) were explored. The positions of various authors concerning priority of medical examination in the process of disability expertise are considered. The article reveals ideas of "active employment" of the disabled, the organization of conditions for full-value functioning of the disabled capable of working in society, various employment opportunities for the disabled, including appeal to creative activity, causes of ineffective involvement of particular categories and groups of the disabled with various diseases into social and labor life. The conclusion is presented that ideas of scientists were not largely in demand in the 1930s, but became the basis of policy of employment of the disabled during the Great Patriotic War, significantly passing ahead of their time.

Resonant properties of the memory capacity of a laser-based reservoir computer with filtered optoelectronic feedback.

We provide a comprehensive analysis of the resonant properties of the memory capacity of a reservoir computer based on a semiconductor laser subjected to time-delayed filtered optoelectronic feedback. Our analysis reveals first how the memory capacity decreases sharply when the input-data clock cycle is slightly time-shifted from the time delay or its multiples. We attribute this effect to the inertial properties of the laser. We also report on the damping of the memory-capacity drop at resonance with a decrease of the virtual-node density and its broadening with the filtering properties of the optoelectronic feedback. These results are interpretated using the eigenspectrum of the reservoir obtained from a linear stability analysis. Then, we unveil an invariance in the minimum value of the memory capacity at resonance with respect to a variation of the number of nodes if the number is big enough and quantify how the filtering properties impact the system memory in and out of resonance.

Complete and partial time-delay signature suppression in a laser array.

We model dynamics of a quantum dot based micropillar laser array subject to the time-delayed optical feedback. The global coupling provided by the feedback generates a rich set of various instabilities including chaotic regimes with strong time-delay signature in the autocorrelation function. We demonstrate that the dispersion of the array coupling phases leads to effective suppression of the time-delay signature due to the dispersion of the system's internal timescales. We find that the transition to the complete suppression of the time-delay signature appears via a chimera state where highly correlated and non-correlated laser outputs coexist. The degree of correlation in the chimera state depends on the coupling phase dispersion.

[Role and importance of forensic medical re-examination of defects in health care delivery]. / Rol' i znachenie povtornoi sudebno-meditsinskoi ekspertizy defektov okazaniya meditsinskoi pomoshchi.

Article is devoted to the problem of production and legal evaluation of repeated commission (complex) forensic medical examinations based on materials of «medical¼ practices, related to facts of health care delivery adverse outcomes, in criminal and civil proceedings. Reasons of re-examination assignment, theoretical and applied aspects of this procedural institute in evidence in cases of iatrogenic crimes and unqualified health care delivery were considered. The authors pay particular attention to deficiency of legal base and practical approaches to the re-examination assignment and its results' evaluation, and suggest ways to improve the forensic medical and law enforcement activity in this category of cases. The examples from practice, illustrating the content and nature of the re-examination's problem in «medical¼ cases, were given, the ways to improve the quality of expert work and judicial practice were emphasized, and measures, that will improve the situation in short term, were identified.

Subharmonic locking and frequency combs in frequency-swept semiconductor lasers.

We analyze a delay differential equation model for a swept semiconductor laser and demonstrate existence of various periodic solutions that are subharmonically locked to the sweep rate. These solutions provide optical frequency combs in spectral domain. We investigate the problem numerically and show that, due to the translational symmetry of the model, there exists a hysteresis loop formed by branches of steady states solutions, bridges of periodic solutions connecting stable and unstable steady state branches, and isolated branches of limit cycles. We discuss the role of bifurcation points and limit cycles embedded into the loop in the formation of the subharmonic dynamics.

Impact of filtering on photonic time-delay reservoir computing.

We analyze the modification of the computational properties of a time-delay photonic reservoir computer with a change in its feedback bandwidth. For a reservoir computing configuration based on a semiconductor laser subject to filtered optoelectronic feedback, we demonstrate that bandwidth selection can lead to a flat-topped eigenvalue spectrum for which a large number of system frequencies are weakly damped as a result of the attenuation of modulational instability by feedback filtering. This spectral configuration allows for the optimization of the reservoir in terms of its memory capacity, while its computational ability appears to be only weakly affected by the characteristics of the filter.

[Statistical analysis of performance indicators of medical forensic departments of the FME bureaux in the Russian Federation]. / Statisticheskii analiz pokazatelei mediko-kriminalisticheskikh podrazdelenii byuro SME v Rossiiskoi Federatsii.

This article presents the results of the study of the quantitative performance indicators of medical forensic departments of state forensic medical expert institutions in Russia as a whole and in individual federal districts from 2009 to 2018. Medical statistics methods were used. We analyzed absolute and intensive indicators, their percentages, and correlation relationships. Trends and patterns were studied to identify causal relationships and assess the effect of various factors. A steady trend of reducing the total number of expert examinations performed in the medical forensic departments was shown. However, their share of the total number of violent death cases is increasing. The labor intensity of medical forensic examinations and the number of examination methods used are increasing. Regional differences in the studied indicators are revealed. The presented metadata can be used to improve the workflow management of forensic medical departments and monitor the effectiveness of improvements. The findings confirm the need to modernize and adapt the regulatory and procedural framework of the expert work.

[Surgical complications in patients with COVID-19]. / Khirurgicheskie oslozhneniya u bol'nykh COVID-19.

OBJECTIVE: To analyze in-hospital perioperative complications in COVID-19 patients. MATERIAL AND METHODS: We analyzed medical records of 1.250 patients with COVID-19 for the period from April 2020 to December 2021. Mean age of patients was 62.8±2.1 years, length of hospital-stay - 44.3±3.7 days. All patients received therapy in accordance with the national guidelines on prevention, diagnosis and treatment of new coronavirus infection (COVID-19)¼ (versions 1-12). Visualization of hematomas, arterial and venous thrombosis was performed using ultrasound, CT and CT angiography. RESULTS: Mortality rate was 1.5%. Surgical complications included various hematomas, arterial and venous thrombosis of great vessels. Hematomas were detected in 15 (1.2%) patients, 2 of them died. There were hematomas of extremities in 5 cases, retroperitoneal space - 4, soft tissues of the body - 4, internal organs (spleen) -2 patients. The volume of hematoma was up to 100 ml in 6 patients, 100-500 ml in 5 patients, 500-1000 ml in 3 patietns, more than 1000 ml in 1 patient. Hematomas occurred in 23.1±1.1 days after laboratory verification of COVID-19. Four (26.7%) patients underwent emergency surgery. Conservative therapy was followed by lysis of hematoma after 25.1±2.7 days. Venous thrombosis without signs of flotation occurred in 20 (1.6%) patients, arterial thrombosis - in 3 (0.24%) patients (2 ones required surgery). CONCLUSION: Management of COVID-19 patients with various hematomas should be as conservative as possible. Arterial thrombosis and extensive spleen hematomas requiring surgical treatment are features of COVID-19.

[Automated digital superimposition of the 3D model and archival photographs of full removable dentures in forensic dentistry]. / Avtomatizirovannoe tsifrovoe issledovanie v sudebno-stomatologicheskoi ekspertize dlya sopostavleniya ob"emnoi modeli i arkhivnykh fotografii polnykh s"emnykh protezov.

THE AIM THE STUDY: The purpose of the work is to perform automated alignment of two-dimensional archival photographs of the first prosthesis and a digital model of the complete removable prosthesis by superposition in order to determine or deny their possible belonging to one user. MATERIALS END METHODS: The superposition was carried out in the Exocad program (DentalCAD 3.0 Galway) using the standard 2D-3D alignment algorithm of the «SmileDesign¼ module; in the same program. In addition, Keynote and Fusion 360, and Autodesk programs were used. Statistical measurements were carried out at the statistically significant level of p<0.05. RESULTS: A comparison of four different-angle and different-scale photographic images of a removable denture of the upper jaw teeth with a three-dimensional copy of the same version of the prosthesis of the life physician of the royal family E.S. Botkin was made. When superimposing a digital three-dimensional model and a two-dimensional photograph of the original prosthesis with marked anthropometric points (n=51), 21 of them coincided or touched each other (41.2%). Another 26 points were located side by side (distance up to 1.5 mm) (50.9%) and 4 did not coincide (distance >1.5 mm, but no more than 3.5-4 mm) (7.8%). When the reference points were combined, the contours, the configuration of the relief and the peripheral boundaries of all three objects mostly coincided. The linear longitudinal and transverse dimensions of the bases of the prostheses also mostly coincided. The exception was the distal border of the bases, and the level of the cutting edges of the anterior artificial teeth, where complete coincidence was not observed, due to differences in the degree of erasability. CONCLUSION: Comparison of the original prosthesis from Ipatiev's house and its stereolithographic model was a test for the accuracy of the matching method used. The stereotype of the compared images is proved and the consistency of the possibility of computer combination of three-dimensional and two-dimensional objects is confirmed. The use of traditional methods of forensic identification and evaluation of the results by methods of mathematical statistics allowed us to conclude that the two different complete removable dentures of the upper jaw depicted in the photographs belong to one user.

[The phenomenon of the formation of a ricocheted buckshot of a negative angle of reflection]. / Fenomen obrazovaniya rikoshetirovavshei kartech'yu otritsatel'nogo ugla otrazheniya.

The purpose of the study is to establish the possibility, determine the conditions and parameters for the formation of a negative angle of reflection of a firearm after a ricochet from the surface of an obstacle based on the results of our own experimental studies. Expert and law enforcement practice shows that after a shot, firearms, both before interaction with an obstacle and after a ricochet, move in space in the same plane with respect to the surface of the obstacle, forming a reflection angle with a positive or zero degree value. As a result of ballistic experiments, the possibility of forming a negative angle of reflection by ricocheted buckshot was established, the conditions and parameters for the occurrence of this pattern were determined. The identified ballistic «Gusentsov phenomenon¼ has an important interdisciplinary scientific and practical significance for further expanding knowledge and understanding of external and internal ballistics and can be successfully used in scientific, practical, forensic and educational activities.

[About the possibility of using a comparative visual method for identification purposes with the participation of specialists in the field of orthopedic dentistry]. / O vozmozhnosti ispol'zovaniya v identifikatsionnykh tselyakh sravnitel'nogo vizual'nogo metoda s uchastiem spetsialistov v oblasti ortopedicheskoi stomatologii.

THE AIM OF THE STUDY: Is to determine whether dentures belong to one or different users. The results of a comparative visual comparison of two different-scale and different-angle photographs of removable dentures of the maxilla teeth are presented. The comparison was carried out by 20 experienced orthopedic dentists. The opinion of the overwhelming majority: with a high degree of probability, the dentures belong to one user. Experts based their judgment on 13 independent attributes. From a forensic medical point of view, the assessment contains elements of subjectivity. The conclusion about the possibility of solving the question posed on the basis of objective methods of forensic identification is formulated.

[Pathomorphological alterations in the kidneys in acute and chronic alcohol intoxication]. / Patomorfologicheskie izmeneniya v pochkakh pri ostroi i khronicheskoi alkogol'noi intoksikatsii.

The literature review presents data on pathomorphological changes in the kidneys in acute and chronic alcohol intoxication. A lack of consensus among researchers on the direct toxic damage to renal tissue by ethanol is demonstrated. Analysis of the literature showed that the issue of attributing microscopic changes detected in the kidneys to characteristic or specific signs remains controversial. Some authors identify several characteristic microscopic patterns in the kidney tissue in alcohol intoxication: thickening of glomeruli basal membranes, narrowing of glomerular capsule tubular lumen. Fatty dystrophy of the proximal tubules is most often indicative of concomitant conditions related to alcohol intoxication, such as ketoacidosis. In alcohol intoxication, some changes in the kidneys occur variably, such as dyscirculatory, dystrophic, pigmentary, necrotic, and autolytic changes. Data on the causes of their occurrence are often contradictory from different authors. The authors of this review believe that this issue can be resolved using up-to-date histochemical, immunohistochemical, and morphometric test methods.

Optical square-wave generation in a semiconductor laser with optoelectronic feedback.

We report self-sustained optical square-wave (SW) generation in a semiconductor laser diode subjected to delayed optoelectronic feedback on its injection current (J). This optoelectronic oscillator relies on nonlinear effects present in both the laser diode and in the optoelectronic feedback loop through amplifier saturation. The repetition rate of the SW is an integer multiple of the inverse of the loop delay, while the duty cycle can be tuned with J.

The damping properties of the foam-filled shaft of primary feathers of the pigeon Columba livia.

The avian feather combines mechanical properties of robustness and flexibility while maintaining a low weight. Under periodic and random dynamic loading, the feathers sustain bending forces and vibrations during flight. Excessive vibrations can increase noise, energy consumption, and negatively impact flight stability. However, damping can alter the system response, and result in increased stability and reduced noise. Although the structure of feathers has already been studied, little is known about their damping properties. In particular, the link between the structure of shafts and their damping is unknown. This study aims at understanding the structure-damping relationship of the shafts. For this purpose, laser Doppler vibrometry (LDV) was used to measure the damping properties of the feather shaft in three segments selected from the base, middle, and tip. A combination of scanning electron microscopy (SEM) and micro-computed tomography (µCT) was used to investigate the gradient microstructure of the shaft. The results showed the presence of two fundamental vibration modes, when mechanically excited in the horizontal and vertical directions. It was also found that the base and middle parts of the shaft have higher damping ratios than the tip, which could be attributed to their larger foam cells, higher foam/cortex ratio, and higher percentage of foam. This study provides the first indication of graded damping properties in feathers.

[Dynamics of fatal injuries in Russian Federation from 2003 to 2019]. / Dinamika smertel'nogo travmatizma v Rossiiskoi Federatsii s 2003 po 2019 g.

OBJECTIVE: Analysis of the violent death structure in the Russian Federation; determination of the changes dynamics in indicators of its main types and identification of the most common ones. Currently, there are no studies with the results of a total data analysis on injuries in the Russian Federation. A number of scientific works devoted to the statistical analysis of injuries touch on short-term periods in individual subjects of the Russian Federation and certain types of injuries. The authors present the results of a detailed analysis of violent death's statistical indicators that can contribute to the monitoring of medical and statistical indicators for the implementation of priority and strategic directions in the health sector, improvement of legal regulation and other measures to strengthen public health and prevent risk factors. The dynamics of changes in various injuries types for the indicated period has been established. The most common types of violent death have been identified; the patterns of decrease and increase in certain death types have been established.