[The interactions along the microbiota-gut-brain axis in the regulation of circadian rhythms, sleep mechanisms and disorders]. / Rol' vzaimosvyazei po osi mozg­kishechnik­mikrobiom v regulyatsii tsirkadiannykh ritmov, mekhanizmakh sna i ikh narushenii.

The bidirectional relationship between cerebral structures and the gastrointestinal tract involving the microbiota embraces the scientific concept of the microbiota-gut-brain axis. The gut microbiome plays an important role in many physiological and biochemical processes of the human body, in the immune response and maintenance of homeostasis, as well as in the regulation of circadian rhythms. There is a relationship between the higher prevalence of a number of neurological disorders, sleep disorders and changes in the intestinal microbiota, which actualizes the study of the complex mechanisms of such correlation for the development of new treatment and prevention strategies. Environmental factors associated with excessive light exposure can aggravate the gut dysbiosis of intestinal microflora, and as a result, lead to sleep disturbances. This review examines the integrative mechanisms of sleep regulation associated with the gut microbiota (the role of neurotransmitters, short-chain fatty acids, unconjugated bile acids, bacterial cell wall components, cytokines). Taking into account the influence of gut dysbiosis as a risk factor in the development of various diseases, the authors systematize key aspects and modern scientific data on the importance of microflora balance to ensure optimal interaction along the microbiota-gut-brain axis in the context of the regulatory role of the sleep-wake cycle and its disorders.

[Hygienic problems of the complex utilization of cleansed sewage water in arid regions]. / Gigienicheskie problemy kompleksnogo ispolzovaniia ochishchennykh stochnykh vod v aridnykh regionakh.

Hygienic criteria of treated sewage quality intended for the use in industry, municipal and agrarian enterprises were suggested.

[The use of physical exercises in the combined treatment of atherosclerosis patients]. / Primenenie fizicheskikh uprazhnenii v kompleksnom lechenii bol'nykh aterosklerozom.

The authors discuss the role of diagnostic biochemical and immunological approaches to evaluation of the curative efficacy of physical training, in particular, its anti-atherosclerotic effects. On the example of the etiopathogenesis of atherosclerosis an analysis is presented of the diagnostic and prognostic value of several tests characterizing the state of metabolism of lipids and lipoproteins, connective tissue, autoimmune processes in curative training.