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[A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. / Polusinteticheskii flavonoid shlemnika baikal'skogo kak sredstvo povysheniia éffektivnosti khimioterapii éksperimental'nykh opukholei.

Razina, T G; Zueva, E P; Litvinenko, V I; Kovalev, I P.

Eksp Klin Farmakol ; 61(2): 54-6, 1998.

Article in Russian | MEDLINE | ID: mdl-9621177

Subject(s)

Antineoplastic Agents, Alkylating/therapeutic use , Carcinoma, Lewis Lung/drug therapy , Cyclophosphamide/therapeutic use , Flavonoids/therapeutic use , Lung Neoplasms/drug therapy , Lymphoma, Non-Hodgkin/drug therapy , Plants, Medicinal/chemistry , Skin Neoplasms/drug therapy , Animals , Drug Screening Assays, Antitumor , Drug Synergism , Male , Mice , Mice, Inbred C57BL , Neoplasm Transplantation , Rats , Rats, Wistar

Amperometric thin film biosensors based on glucose dehydrogenase and Toluidine Blue O as catalyst for NADH electrooxidation.

Boguslavsky, L I; Geng, L; Kovalev, I P; Sahni, S K; Xu, Z; Skotheim, T A; Laurinavicius, V; Persson, B; Gorton, L.

Biosens Bioelectron ; 10(8): 693-704, 1995.

Article in English | MEDLINE | ID: mdl-7576437

ABSTRACT

Amperometric glucose sensors were constructed based on solid graphite electrodes, surface-modified with NAD+ dependent glucose dehydrogenase (GDH), Toluidine Blue O (TBO), and protective ionic polymers. The electrocatalytic oxidation of NADH was evaluated from cyclic voltammetry with TBO dissolved, adsorbed, and electrostatically or covalently bound to polymers. The NADH and glucose sensors constructed were investigated and operated at 0 mV vs. Ag/AgCl using single potential step chronoamperometry. The operational stability of the glucose sensors was limited by leakage of NAD+. A glucose sensitivity much higher than carbon paste electrode was found. A sensitivity as high as 25 microA cm-2 mM-1 was achieved.

Subject(s)

Biosensing Techniques , Glucose Dehydrogenases , Glucose/analysis , NAD/analysis , Tolonium Chloride , Enzymes, Immobilized , Glucose 1-Dehydrogenase , Oxidation-Reduction

[Interaction of IR-21 stoppers with neutral solutions for injections]. / Vzaiemodiia probok IR-21 neitral'nymy rozchynami dlia in'iektsii

Bondar', V S; Konev, F A; Kovalev, I P; Kulesh, K F.

Farm Zh ; 31(5): 68-71, 1976.

Article in Ukrainian | MEDLINE | ID: mdl-16773

Subject(s)

Drug Packaging , Solutions/pharmacology , Drug Interactions , Hydrogen-Ion Concentration , Injections , Kinetics

[Study of the mechanism of the oximation reaction of some carbonyl-containing compounds]. / Vyvchennia mekhanizmu reaktsiï oksymuvannia deiakykh karbonilvmisnykh spoluk

Dziuba, N P; Kazarinov, N A; Kovalev, I P; Marinin, V S.

Farm Zh ; 31(3): 55-9, 1976.

Article in Ukrainian | MEDLINE | ID: mdl-939299

Subject(s)

Oximes/chemical synthesis , Aldehydes/pharmacology , Cardiac Glycosides/pharmacology , Chemistry, Pharmaceutical , Chromones/pharmacology , Furans/pharmacology , Ketones , Spectrophotometry, Infrared , Steroids/pharmacology

[Stereochemistry of some optically active coumarin derivatives. II]. / Stereokhimiia deiakykh optychno aktyvnykh pokhidnykh kumarynu. Povidomlennia II

Kovalev, I P; Shelkovoi, V D; Gordienko, V G; Prokopenko, A P.

Farm Zh ; (2): 43-7, 1976.

Article in Ukrainian | MEDLINE | ID: mdl-1269696

Subject(s)

Coumarins/analysis , Chemical Phenomena , Chemistry, Physical , Molecular Conformation , Optical Rotatory Dispersion , Stereoisomerism

[Stereochemistry of some optically active coumarin derivatives. I]. / Sterokhimiia deiakykh optychno aktyvnykh pokhidnykh kumarynu. Povidomlennia I

Kovalev, I P; Shelkovoi, V D; Prokopenko, A P.

Farm Zh ; (5): 44-7, 1975.

Article in Ukrainian | MEDLINE | ID: mdl-1225556

Subject(s)

Coumarins/analysis , Chemical Phenomena , Chemistry, Physical , Molecular Conformation , Optical Rotatory Dispersion , Stereoisomerism

[Bidens tripartita flavonoids. The absolute configuration of isocoreopsin]. / Flavonoïdy Bidens tripartita. Absoliutna konfihuratsiia izokoreopsynu

Serbin, A G; Borisov, M I; Chernobai, V T; Kovalev, I P; Gordienko, V G.

Farm Zh ; (2): 88-9, 1975.

Article in Ukrainian | MEDLINE | ID: mdl-1140373

Subject(s)

Flavonoids/analysis , Plants, Medicinal/analysis , Molecular Conformation , Spectrophotometry , Ukraine

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