[Catecholamine excretion in patients with eating disorders].

OBJECTIVE: To compare clinical features of eating disorders and parameters of monoamine metabolism. MATERIAL AND METHODS: Authors examined 21 patients with eating disorders during 2008-2011 using clinical/psychopathological method. To evaluate the status of monoamine neuromediator system, urine levels of dopamine, noradrenalin and adrenaline excretion were measured using high-yield liquid chromatography with electrochemical detection. The reference group included 26 sex- and age-matched volunteers. RESULTS AND CONCLUSION: The common patterns of the pathogenesis of compulsive urges of different origin were identified. The results indicate not only nonspecific changes in catecholamine systems of patients with eating disorders associated with different stress disorders but also demonstrate the pathogenetic correlations between dopaminergic activity and clinical symptoms of addiction.

[Monoamine metabolism in different forms of paraphilias]. / Obmen monoaminov pri razlichnykh formakh parafilii.

42 persons which commited crime sexual actions were examined in terms of clinical and neurochemical investigations. The sexual behaviours of 31 patients from this group were associated with sexual inclination pathology--with paraphilia. The patients were divided into 2 groups namely with compulsive form of paraphilia (13 individuals) and without compulsive disturbances (18 patients). Both free and conjugated forms of norepinephrine (NA), dopamine (DA), dihyroxyphenylalanine (DOPA) and dihyroxyphenylacetic acid (DOPAC) were measured in serum and daily urine as well as serotonin concentration was estimated in blood plasma and platelets. The rate of 3H-serotonin uptake into platelets (Vmax) was also investigated. It was determined that Vmax, free and especially conjugated forms of NA, DA, DOPAC levels were significantly higher in patients with compulsive forms of paraphilia. It was supposed that monoamine mechanisms may be operated in psychopathological variations of the crime sexual behaviour.

[Catecholamines and the dopamine-beta-hydroxylase activity of the blood plasma in motor pathology in children: the role of central and peripheral mechanisms]. / Katekholaminy i aktivnost' dofamin-beta-gidroksilazy plazmy krovi pri dvigatel'noi patologii u detei: rol' tsentral'nykh i perifericheskikh mekhanizmov.

Plasma catecholamine levels and serum dopamine-beta-hydrolase (D beta H) activity were investigated using high-performance chromatography and spectrophotometry, respectively, in 32 patients aged 10-14 with various motor pathology. Group 1 patients (21 children with spastic diplegia and clinical signs of central catecholaminergic neuromediation deficiency) received Nakom in a single daily dose 60 mg in the morning. The treatment produced a good clinical effect. Six children of group 2 with hereditary degenerative cerebral, spinal, nervous diseases and 5 children of group 3 with lower spastic paraplegia consequent to spinal cord trauma inflicted 6-12 months: before received Nakom in a single daily dose 30 mg in the morning for 14 days. The treatment in them resulted in an essential decrease of pelvic dysfunctions. All the children had a high DOPA level in blood plasma irrespective of the group and Nakom administration. Pretreatment dopamine (DA) levels were different: the least in cerebral palsy patients (0.019 +/- 0.01 ng/ml), the highest in group 2 (p < 0.05), in children with spinal cord pathology it was higher than normal and higher than in group 1 (p < 0.001). Nakom treatment promoted DA normalization in all the groups. Norepinephrine (NE) concentrations were very low in all the patients correlating with the degenerative process degree and did not change in response to Nakom administration. D beta H activity was inhibited in all the groups, especially in the spinal patients. Nakom increased both D beta H activity (p < 0.01) and motor activity. Thus, an increased DOPA level is plasma is not specific for nervous diseases.(ABSTRACT TRUNCATED AT 250 WORDS)

[Myocardial contractility and hemodynamic indicators in newborn infants with acute respiratory viral infections]. / Sokratitel'naia sposobnost' miokarda i pokazateli gemodinamiki u novorozhdennykh, bol'nykh ostrymi respiratornymi virusnymi infektsiiami.

A study was made of myocardial contractility, of the central and peripheral hemodynamics in infants with acute respiratory viral infections. Stable disorders of the phasic structure of contraction and relaxation of the left and right ventricles of the heart combined with an appreciable rise of the pressure in the pulmonary artery were disclosed. It has been found necessary to administer both remedies improving myocardial metabolism and cardiotonic drugs. The high pressure persisting in the pulmonary artery which resulted in heart fatigue in the neonates with acute respiratory viral infections bears witness to inadequacy of the euphylline dosage used.