[Morpho-functional characteristic of the lumbar area of the human vertebral column in the individuals with various degrees of lumbar lordosis (on the basis of three-dimensional computer modeling)].

This investigation was aimed at the evaluation of the borders of individual variability of the human lumbar spine lordosis. 224 nuclear magnetic tomograms of persons of mature age were analyzed using morphometric, statistical methods, method of three-dimensional (3D) computer modeling and finite-element analysis. During the investigation, a hardware-software complex for morphometric research was created together with the new method of development of 3D computer models of the lumbar spine. The application of 3D modeling allowed to extend the knowledge of human spine biomechanics. Tensions and deformations were calculated in all lumbar vertebrae and intervertebral disks on the basis of spine 3D models developed. Finite-element analysis proved that a normal angle of lumbar lordosis was optimal for the transmission of the adequate compression loads, while the extreme forms of individual variability (high degrees of hyper- and hypolordosis), by changing the geometry of the vertebral column, result in the decrease of the functionality of this system.

[Use of immune and cytogenetic tests to assess the effect of different anthropogenic factors on the human organism in a large industrial region setting]. / Primenenie immunnykh i tsitogeneticheskikh testov dlia otsenki vliianniia na organizm cheloveka razlichnykh faktororv antropogennogo proiskhozhdeniia v usloviiakh krupnogo promyshlennogo regiona.

A feasibility is analyzed of our using a complex of immunological and cytogenetic investigations to assess the impact of adverse factors of antropogenic origination, chemical and radiation ones in particular, on the immune system and genetic apparatus in those persons residing under conditions of a large industrial region. Identified in the above subjects was the presence of different variants of secondary immunological insufficiency, chromosome and chromatid aberrations in liquidators of the effects of the Chornobyl accident, workers of chemicals--, by-product coke plants, and metallurgical works, the degree of the above insufficiency being decided by ecological conditions of residence, presence of occupational hazards, their nature, and duration of exposure.

[Osteogenesis during the correction of burns with alpha-tocopherol]. / Osteogenez pri korrektsii ozhogovoi bolezni al'fa-tokoferolom.

Macro- and microscopic transformations were studied in burned animals skeleton after treatment with alpha-tocopherolum. The antioxidant was found to optimize osteogenesis, disturbed in burn lesion.

[The proliferative processes in the skeleton of white rats administered dipal experimentally and after antioxidant therapy with tocopherol]. / Proliferativnye protsessy v skelete belykh krys pri éksperimental'nom vvedenii dipala i antioksidantnoi terapii tokoferolom.

Specific features of osteogenesis under a toxic action of pesticide Dipal and antioxidation therapy with tocopherol were studied in experiments in inbred albino rats by the method of autoradiography with 3H-thymidine label. The index of labeled nuclei and intensity of the label in chondroblasts and osteoblasts of the epiphyseal cartilage and periosteum of the middle third of the tibia diaphysis were counted in the light autoradiograms. The method of electron autoradiography was used for the identification of DNA-synthesizing osseous and cartilaginous cells and for studying their ultrastructure. The age-related and topographic activity of the proliferative osteogenic processes, their correlation with the degree of the toxic injury of the organism was established. Dipal, as an osteotropic drug, inhibits proliferative processes in the blast osseous and cartilaginous cells, sharply decreasing the index of labeled nuclei and the label intensity. Correction with tocopherol levels the degree of processes of the inhibition of osteogenesis.

[Comparative morphometric analysis of the reaction of the rat bone to dehydration and burn trauma]. / Sravnite'lnyi morfometricheskii analiz reaktsii kostei krys na degidratatsiiu i ozhogovuiu travmu.

The epiphyseal cartilage and diaphysis of the tibia have been studied at dehydration and burn trauma. Dehydration produces certain disturbances in growth and formation of the bone, and burn trauma--development of dystrophic changes.