ABSTRACT
PURPOSE: To obtain simultaneous 24-hour contact lens voltage and systemic arterial blood pressure values with the Sensimed Triggerfish system and Holter monitoring device. METHODS: Ten primary open-angle glaucoma (POAG) and 8 pseudoexfoliation glaucoma (PXG) patients were included in the study. The Sensimed Triggerfish contact lens device was used to calculate the 24-hour IOP, and a Holter sphygmomanometer device was used for simultaneous 24-hour blood pressure measurements. We define the 8:00 am-11:00 pm period measurements as diurnal values and the other measurements as nocturnal values. RESULTS: The mean nocturnal systolic values (nocturnal SBP 120.5±3.4 for POAG and 122.8±5.3mmHg for PXG) and diastolic BP (nocturnal DBP 70.2±1.9 for POAG and 68.1±1.2mmHg for PXG) were lower than the diurnal (diurnal SBP 134.6±5.3 for POAG, 145.9±41.7mmHg for PXG, diurnal DBP 79.4±5.8 for POAG and 78.6±5.1mmHg for PXG) values, and these differences were statistically significant in both groups (P=0.001 in DBP in PXG and P<0.001 for other values). In addition, nocturnal CL voltage values (228.8±41.1 for POAG and 214.3±47.0mVEq for PXG) were higher than the diurnal values (55.8±77.2 for POAG and 145.9±41.7mVEq for PXG) in the POAG and PXG groups, and these were statistically significant as well (P<0.001 for all). In the POAG and PXG groups, CL voltage had a statistically significant negative correlation with systolic (respectively, r: -0.248, P=0.001 and r: -0.272, PË0.001) and diastolic (respectively, r: -0.115, P=0.036 and r: -0.160, P=0.028) BP values. CONCLUSION: We observed that CL voltage values rose during the nocturnal period, with a concomitant decrease in systolic and diastolic BP.
Subject(s)
Blood Pressure Monitoring, Ambulatory , Blood Pressure/physiology , Exfoliation Syndrome/physiopathology , Glaucoma, Open-Angle/physiopathology , Intraocular Pressure/physiology , Tonometry, Ocular , Aged , Blood Pressure Monitoring, Ambulatory/instrumentation , Blood Pressure Monitoring, Ambulatory/methods , Blood Pressure Monitors , Circadian Rhythm/physiology , Exfoliation Syndrome/diagnosis , Female , Glaucoma, Open-Angle/diagnosis , Humans , Male , Middle Aged , Time Factors , Tonometry, Ocular/instrumentation , Tonometry, Ocular/methodsABSTRACT
PURPOSE OF INVESTIGATION: Gonadotropin stimulated intrauterine insemination (IUI) cycles performed following one month after hysterosalpingography (HSG) are associated with improvement in clinical pregnancy rates in unexplained infertile couples. MATERIALS AND METHODS: A retrospective cohort study was performed between 2008 and 2014. A total of 92 unexplained infertile couples undergoing their first cycle IUI stimulated by gonadotropins were included in the analysis. Participants were classified into two groups according to IUI cycles performed one month (Group A, n = 25 cycles) or longer than one month (Group B, n = 67 cycles) after the HSG procedure. RESULT: The overall clinical pregnancy rate was found as 25% (23 clinical pregnancies / 92 cycles). Clinical pregnancy rate was 44 % (11/25) for Group A and 17.9 % (12/67) for Group B. In Group A, there were significantly higher clinical pregnancy rates compared to Group B (OR: 3.6, 95% CI, 1.3-9.8; p = 0.012). CONCLUSIONS: It has been demonstrated that fertility improving effect of HSG was most prominent in the first six months after procedure. Likewise, in gonadotropin stimulated IUI cycles performed following one month after HSG, there seems to be an improvement in pregnancy rates in unexplained couples. In unexplained cases, it may be a reasonable approach to plan IUI cycles in the first month after HSG in clinical practice.
