[MIRU-VNTR genotyping of Mycobacterium tuberculosis strains from East Siberian: Beijing family versus Kilimanjaro family]. / MIRU-VNTR-genotipirovanie shtammov Mycobacterium tuberculosis v Vostochnoi Sibiri: semeistvo Beijing protiv Kilimanjaro.

Seventy-two M. tuberculosis strains isolated from patients in different regions of East Siberia were studied by MIRU-VNTR repeats. Phylogenetic trees of relationship between the studied strains and of those from other world regions were investigated by phylogenetic analysis, i.e. NJ, UPGMA and ML. Phylogenetic evidence is provided for the prevalence of Beijing and Beijing-like strains (71%) in the above region. Besides, there was found a group of strains (115%) with the robust genotype which was given the name of ASU (African-Siberian-Ural). A linkage between MIRU10 (5-10 repeat) and MIRU26 (single repeat) was established as a predominant ASU sign. According to preliminary results, apart from Siberia, ASU strains can be encountered in the Urals and Africa (Tanzania, Kilimanjaro genotype). MIRU-VNTR consensus of ASU for East Siberia is 22( > 6)225113233.

[Efficacy of BCG vaccination]. / K voprosu éffektivnosti vaktsinatsii BTsZh.

Adults born in 1961-1962 and later were found to have skin vaccination marks by 3 times more less those born before this period. The high risk of diseases in young individuals from the family contact inoculated with BCG vaccine was due to massive superinfection. The incidence of tuberculosis in individuals under latent tuberculous infection is promoted by no or low-grade BCG vaccination.