ABSTRACT
OBJECTIVE: To study the possibilities of enhancing the efficiency of differential diagnosis of solitary lung masses by optimizing the quantitative analysis of positron emission tomography (PET) data when two radiopharmaceuticals (RP) (18F-fluorodeoxyglucose (18F-FDG) and 11C-methionine) are used alone and in combination. MATERIAL AND METHODS: A comprehensive examination involving 18F-FDG and 11C-methionine PET was made in 116 patients with solitary lung masses of various genesis. A final diagnosis in the examinees was established from the results of postoperative material morphological analysis and/or laboratory tests and those of X-ray follow-up. RESULTS: No 18F-FDG and 11C-methionine hyperfixation was found in patients with benign tumors and in the majority of patients with focal pneumofibrosis. At 18F-FDG and 11C-methionine PET, RP accumulation was recorded in all patients with lung cancer (LC) and in patients with inflammatory diseases. Three patients with 18F-FDG PET-negative typical carcinoid tumors were noted to have increased 11C-methionine uptake. At 11C-methionine PET, RP accumulation was recorded in the projection of formation in all the patients with LC and in 38 of the 42 patients with inflammatory diseases. Regardless of the used RP, the Standardized Uptake Value (SUV) was significantly lower in the patients with inflammatory diseases than in those with LC (p ≤ 0.05). CONCLUSIONS: When RP is used alone, the diagnostic efficiency of C-methionine PET in the differential diagnosis of lung tumors and inflammations is higher than that of 18F-FDG PET. At the same time, the highest PET is seen when 18F-FDG and 11C-methionine are used in combination.
Subject(s)
Fluorodeoxyglucose F18 , Lung Neoplasms/diagnosis , Methionine , Positron-Emission Tomography/methods , Solitary Pulmonary Nodule/diagnosis , Adult , Data Interpretation, Statistical , Diagnosis, Differential , Female , Humans , Male , Radiopharmaceuticals , Reproducibility of Results , Sensitivity and SpecificitySubject(s)
Abdominal Injuries/surgery , Digestive System Surgical Procedures/methods , Drainage/methods , Lung Injury/surgery , Multiple Trauma/surgery , Abdominal Injuries/diagnosis , Accidents, Traffic , Follow-Up Studies , Humans , Lung Injury/diagnosis , Male , Multiple Trauma/diagnosis , Severity of Illness Index , Young AdultABSTRACT
The article presents a generalized experience with treatment of 49 patients with malignant stenosis of the trachea complicated by respiratory insufficiency. Different methods of endoscopic recanalization of the stenosed portion of the trachea are analyzed. Factors are shown influencing the outcome of urgent restoration of patency of the respiratory pathways. Exact indications are proposed on carrying out self-locking stents in patients with malignant damage of the trachea, and the sequence of actions in patients with decompensated stenosis of the trachea of malignant nature.
Subject(s)
Carcinoma, Squamous Cell/pathology , Carcinoma, Squamous Cell/surgery , Tracheal Neoplasms/pathology , Tracheal Neoplasms/surgery , Tracheal Stenosis/etiology , Acidosis, Respiratory/etiology , Aged , Bronchoscopy , Female , Humans , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm Staging , Postoperative Complications , Tracheal Stenosis/diagnosisABSTRACT
Lung transplantation is one of the most difficult fields of contemporary transplantology. The operation was performed on a 53-year-old female who had been suffering from terminal stage COPD. The period of cold ischemia for the right and left lung was 1 hour 30 minutes and 2 hours 25 minutes respectively. The total operation time was 4 hours and 40 minutes. There were no surgical complications. There were no signs of transplant rejection 6 weeks after the operation. The considerable decrease in dispnea and increase in quality of life were registered during the follow-up. FEV1 was increased by 80% and 6 minute walk test distance was increased by 200 meters.
