1.
Chem Asian J
; 17(4): e202101299, 2022 Feb 14.
Article
in English
| MEDLINE
| ID: mdl-34927372
ABSTRACT
A novel N,N-dibenzyl diaminomethylenemalononitrile organocatalyst efficiently promoted asymmetric Henry reactions of trifluoromethyl enones with nitromethane, affording corresponding highly functionalized products in high yields with excellent enantioselectivities (up to 90% ee). This study is the first to report the successful example of the asymmetric 1,2-additions of nitromethane to trifluoromethyl enones.