Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 18 de 18
Filter
Add more filters










Publication year range
2.
Heart Surg Forum ; 8(1): E72-4, 2005.
Article in English | MEDLINE | ID: mdl-15769721

ABSTRACT

We present a case of an asymptomatic cavernous hemangioma, located in the junction area between the left atrium and aorta, and our experience of diagnosis and surgical treatment of the tumor.


Subject(s)
Cardiopulmonary Bypass , Echocardiography , Heart Neoplasms/diagnostic imaging , Heart Neoplasms/surgery , Hemangioma, Cavernous/diagnostic imaging , Hemangioma, Cavernous/surgery , Aorta , Heart Atria , Heart Neoplasms/pathology , Hemangioma, Cavernous/pathology , Humans , Male , Middle Aged
3.
Pacing Clin Electrophysiol ; 26(1P2): 507-10, 2003 Jan.
Article in English | MEDLINE | ID: mdl-12687879

ABSTRACT

It has been shown in animals and humans that AF shortens the atrial refractory period and impairs its rate adaptation. The aim of the study was to evaluate the effects of high rate pacing on sinus node function and intraatrial conduction. Eight dogs were subjected to rapid atrial pacing (AP) at a rate of 400 beats/min for 16 days. After a complete recovery of left ventricular function, they underwent rapid ventricular pacing (VP) at 240 beats/min of equal duration. Sinus node recovery time (SNRT) was measured after pacing at 150, 160, and 170 beats/min. P wave duration was measured on a surface ECG recorded at a paper speed of 200 mm/s. Measurements were performed at baseline, immediately after AP or VP, and four weeks after termination of AP or VP. SNRT immediately after AP and VP was significantly prolonged at all three pacing rates (P < 0.03). P wave duration increased significantly after either type of pacing (AP: 74.3 +/- 6.4 ms, VP: 70.0 +/- 3.8 ms) compared with baseline values (60.6 +/- 6.2 ms, P < 0.05). Rapid AP and VP induces sinus node dysfunction and prolongs intraatrial conduction time. The effects of sustained AP and VP on sinus node function and atrial myocardium returned toward control values 4 weeks after cessation of pacing. The authors hypothesize that reversible electrical remodeling occurs both in the sinus node and in the atrial myocardium.


Subject(s)
Arrhythmia, Sinus/etiology , Cardiac Pacing, Artificial/adverse effects , Heart Conduction System/physiopathology , Animals , Cardiac Pacing, Artificial/methods , Dogs , Heart Atria/innervation
4.
Pflugers Arch ; 442(6 Suppl 1): R195-7, 2001.
Article in English | MEDLINE | ID: mdl-11678337

ABSTRACT

Rapid atrial activation causes electrical remodeling that promotes the occurrence and maintenance of atrial fibrillation. The aim of this research was to compare the relationship between mechanical remodeling and atrial electrophysiology. Eight dogs (beagles) were subjected to rapid atrial pacing (AP) at 400 beats/min for 16 days. After a complete recovery of electrical variables and left ventricular function evaluated by echocardiography, they underwent high-rate ventricular pacing (VP) at 240 beats/min of equal duration. In half of them, the study was started by VP and in the other half by AP. Left atrial systolic function was assessed by transesophageal echocardiography. Atrial effective refractory period (AERP) at a basic cycle length of 400 ms decreased significantly after either type of pacing (AP: 115 +/- 17 ms, VP: 136 +/- 22 ms) compared with baseline values (153 +/- 23 ms); the difference between tachycardias was significant too (p < 0.02). Significant increases (p < 0.05) in left atrial dimensions (LA-A) (AP: 2.41 +/- 0.23 cm ,VP: 2. 43 +/- 0. 34 cm vs. basal: 2. 16 +/- 0. 21 cm) indicated atrial dilatation after either type of pacing, the differences between two groups being insignificant. Atrial reversal pulmonary venous flow (AR velocity) decreased in AP (-0.13 +/- 0. 02 m/s) and VP (-0. 17 +/- 0. 04 m/s). The difference was highly significant as compared to basal values (-0.25 +/- 0.05 m/s) and also with respect to both tachycardias (p < 0.01). In both groups, atrial remodeling occurred in a relatively short period of time. The echocardiographic findings suggested that left atrial systolic function was significantly more disturbed in the AP group than in the VP group. Mechanical changes are an important substrate of electrical remodeling, yet the deterioration of electrical variables was more pronounced in AP than in VP.


Subject(s)
Atrial Fibrillation/physiopathology , Atrial Function, Left/physiology , Systole/physiology , Animals , Atrial Fibrillation/diagnostic imaging , Disease Models, Animal , Dogs , Echocardiography, Transesophageal , Heart Atria/physiopathology , Heart Conduction System/physiology , Pacemaker, Artificial , Ventricular Function , Ventricular Remodeling/physiology
5.
Lupus ; 10(11): 815-7, 2001.
Article in English | MEDLINE | ID: mdl-11789492

ABSTRACT

We describe a case of a 45-y-old woman with a left atrial myxoma, mild to moderate constitutional symptoms and systemic embolisms. Increased levels of antiphospholipid antibodies were detected at admission to the hospital and were gradually normalized after the surgical removal of the tumor. It is known that myxomas have the peculiar ability to induce a systemic inflammatory state with constitutional symptoms, probably mediated by the production of inflammatory mediators in the tumor. This case suggests that myxomas might have also been implicated in the production of antiphospholipid antibodies. Antiphospholipid antibodies could be just a by-product of the systemic inflammatory response. However, they could also have a role in the thrombosis on the myxoma surface and systemic embolisms.


Subject(s)
Antibodies, Anticardiolipin/blood , Embolism/immunology , Heart Neoplasms/immunology , Myxoma/immunology , Embolism/complications , Female , Glycoproteins/immunology , Heart Atria , Heart Neoplasms/complications , Heart Neoplasms/surgery , Humans , Immunoglobulin G/blood , Immunoglobulin M/blood , Interleukin-6/blood , Lupus Coagulation Inhibitor/blood , Middle Aged , Myxoma/complications , Myxoma/surgery , beta 2-Glycoprotein I
6.
Pediatr Hematol Oncol ; 17(7): 527-40, 2000.
Article in English | MEDLINE | ID: mdl-11033728

ABSTRACT

Long-term leukemia survivors (46) underwent cardiac evaluation, including physical examination, ECG, exercise testing, and echocardiography. They were 2-17 years old at diagnosis and 5-23 years old after treatment. Thirty-four survivors received anthracyclines (AC) (mean 203 mg/m2), 12 of them had also alkylating agents (AA) and 12 had no AC. Exercise tolerance was bellow predicted values in 21 (48%) survivors and 21 survivors had ECG abnormalities, which were more frequent in those treated with AC. Concomitant AC with AA was correlated with prolonged isovolumic relaxation time (IVRT) and influenced significantly the volume of left atrium (p = .02). Sixteen (52%) survivors had IVRT > or = 90 ms. There were no significant differences in other parameters of diastolic or systolic function. Despite the lack of clinical symptoms in the survivors treated with lower doses of AC, subtile abnormalities in myocardial function were found, mainly manifest as abnormal diastolic function. Prolonged IVRT may be a sensitive indicator for early detection of AC cardiotoxicity.


Subject(s)
Antibiotics, Antineoplastic/adverse effects , Heart Diseases/chemically induced , Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy , Adolescent , Adult , Antibiotics, Antineoplastic/administration & dosage , Antibiotics, Antineoplastic/therapeutic use , Antineoplastic Agents, Alkylating/administration & dosage , Antineoplastic Agents, Alkylating/adverse effects , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Child , Child, Preschool , Echocardiography, Doppler , Electrocardiography/drug effects , Electrocardiography/methods , Exercise Test , Female , Follow-Up Studies , Heart Diseases/diagnosis , Heart Diseases/diagnostic imaging , Humans , Male , Risk Factors
7.
Pflugers Arch ; 439(3 Suppl): R50-2, 2000.
Article in English | MEDLINE | ID: mdl-10653140

ABSTRACT

Hereditary pancreatitis (HP) is an autosomal dominant disorder characterized by recurrent acute attacks of severe abdominal pain with an onset in early childhood. Many HP patients progress to complicated chronic pancreatitis and/or pancreatic cancer. Initially, a single mutation R117H in the cationic trypsinogen gene was detected in all affected members of five unrelated HP families. Further studies identified a second mutation (N21L) in two HP families without the R117H mutation. Before the association between cationic trypsinogen and HP was found, we detected a cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation (L327R) in all affected individuals of a family with HP. We therefore performed a mutational analysis for R117H and N21L in cationic trypsinogen in this and three additional unrelated families with HP. The R117H mutation was detected in all 9 affected members of three HP families and in 3 asymptomatic but at-risk relatives. However, neither the R117H nor the N21L mutation in the cationic trypsinogen were found in the HP family with the L327R alteration in CFTR. The L327R allele segregates with the disease within this HP family and was not detected on 360 unrelated Caucasian non-CF chromosomes. Although close to 800 different mutations have been detected in the CF gene of cystic fibrosis patients, L327R is a new alteration, not yet reported in connection with CF. The results of this study indicate that the CFTR gene may play a role in the etiology of minority of cases with HP and suggest that hereditary pancreatitis is genetically heterogeneous disease.


Subject(s)
Genetic Variation , Pancreatitis/genetics , Chromosome Mapping , Cystic Fibrosis Transmembrane Conductance Regulator/genetics , Heterozygote , Humans , Mutation/genetics , Polymerase Chain Reaction , Polymorphism, Single-Stranded Conformational , Trypsinogen/genetics
8.
Circulation ; 101(3): E44, 2000 Jan 25.
Article in English | MEDLINE | ID: mdl-10650064
9.
11.
Pediatr Cardiol ; 19(5): 420-1, 1998.
Article in English | MEDLINE | ID: mdl-9703570

ABSTRACT

A case of aneurysmal enlargement of the right atrium was found accidentally during a routine examination. The patient was asymptomatic and free of palpitations or proven rhythm disturbances. The results of echocardiography, magnetic resonance imaging, and cardiac catheterization excluded cardiac malformation, which could have caused secondary enlargement of the right atrium. A partial pericardial defect as a likely cause of herniation of the right atrium was ruled out by magnetic resonance imaging. In keeping with these results, isolated aneurysmal enlargement of the right atrium was diagnosed.


Subject(s)
Cardiomegaly/etiology , Coronary Aneurysm/diagnosis , Heart Atria , Adolescent , Coronary Aneurysm/complications , Dilatation, Pathologic , Heart Atria/pathology , Humans , Male
12.
J Infect ; 35(1): 81-2, 1997 Jul.
Article in English | MEDLINE | ID: mdl-9279731

ABSTRACT

A patient with recurrent fungal endocarditis on prosthetic mitral valve is presented. Candida parapsilosis was the causative agent. The patient was treated medically with conventional amphotericin during the first episode. When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects. Treatment was continued with amphotericin B colloidal dispersion, followed by fluconazole for 8 months. The patient is healthy 16 months after discontinuation of fluconazole. Medical treatment of fungal endocarditis on prosthetic valves can be successful in selected cases.


Subject(s)
Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Candidiasis/drug therapy , Endocarditis/drug therapy , Fluconazole/therapeutic use , Heart Valve Prosthesis/adverse effects , Prosthesis-Related Infections/drug therapy , Endocarditis/microbiology , Female , Humans , Middle Aged , Recurrence
13.
J Electrocardiol ; 30(2): 109-11, 1997 Apr.
Article in English | MEDLINE | ID: mdl-9141605

ABSTRACT

A patient with spontaneous left-sided pneumothorax and unusual, phasic voltage variations in the electrocardiogram (ECG), which fluctuated depending on respiration, was observed. After intercostal tube drainage, these variations disappeared. The respiratory changes in the thorax seem to be a cause of these ECG findings.


Subject(s)
Electrocardiography , Pneumothorax/physiopathology , Adult , Diagnosis, Differential , Drainage , Humans , Male , Myocardial Ischemia/diagnosis , Pneumothorax/diagnostic imaging , Pneumothorax/etiology , Pneumothorax/therapy , Radiography, Thoracic , Tuberculosis, Pulmonary/complications
15.
Int J Cardiol ; 56(1): 75-81, 1996 Sep.
Article in English | MEDLINE | ID: mdl-8891808

ABSTRACT

Long-standing ventricular tachycardia (VT) and supraventricular tachycardia (SVT) can produce a reversible left ventricular dysfunction. The onset of cardiomyopathy and the severity of posttachycardic changes depend at least on three parameters of tachycardia, including its type (VT or SVT), rate and duration. Ten dogs (beagles) were paced at 180 beats/min for 3 weeks. Two pacing modalities, supraventricular and ventricular, were used in each dog. In half of them, the study was started by ventricular, and in the other half by supraventricular high-rate pacing. The alternate pacing modality was applied after complete recovery of left ventricular function. Ventricular function and morphology were evaluated by radionuclide ventriculography, echocardiography and Swan-Ganz catheterisation. Posttachycardic changes were studied in sinus rhythm after cessation of pacing. Left ventricular ejection fraction (LVEF) fell significantly after either type of tachycardia (SVT: 53 +/- 5%, VT: 48 +/- 7%, P < 0.05) compared with baseline values (69.5 +/- 2.3%). Significant increases (P < 0.05) in end-systolic (SVT: 2.1 +/- 0.3 cm, VT: 2.4 +/- 0.2 cm vs. 1.6 +/- 0.3 cm) and end-diastolic dimensions (SVT: 3.0 +/- 0.3 cm, VT: 3.3 +/- 0.4 cm vs. 2.7 +/- 0.3 cm) indicated ventricular dilation in paced animals. Left ventricular pulmonary capillary wedge pressure increased significantly after either type of tachycardia as compared with baseline values (SVT: 7.5 +/- 1.2 mmHg, VT: 8.4 +/- 1.1 mmHg vs. 1.9 +/- 1.5 mmHg, P < 0.05); the difference between tachycardias was not significant. The present study demonstrates that chronic SVT and VT result in left ventricular dysfunction in a relatively short time, even if the heart rate is not very high. Deterioration of left ventricular ejection fraction and dilation of the left ventricle are more marked in chronic VT than in chronic SVT.


Subject(s)
Cardiomyopathies/etiology , Tachycardia, Supraventricular/complications , Tachycardia, Ventricular/complications , Ventricular Dysfunction, Left/etiology , Animals , Cardiac Pacing, Artificial , Cardiomyopathies/diagnosis , Cardiomyopathies/physiopathology , Catheterization, Swan-Ganz , Chronic Disease , Dogs , Echocardiography , Follow-Up Studies , Radionuclide Ventriculography , Random Allocation , Tachycardia, Supraventricular/physiopathology , Tachycardia, Supraventricular/therapy , Tachycardia, Ventricular/physiopathology , Tachycardia, Ventricular/therapy , Ventricular Dysfunction, Left/diagnosis , Ventricular Dysfunction, Left/physiopathology
16.
Angiology ; 47(5): 501-6, 1996 May.
Article in English | MEDLINE | ID: mdl-8644947

ABSTRACT

The authors present 3 patients with asymmetric hypertrophic cardiomyopathy, which was diagnosed by echocardiography. Magnetic resonance imaging, however, proved superior in visualizing the cardiac anatomy of the left ventricle and enabled myocardial evaluation with determination of the location, severity, and extent of the abnormality. Magnetic resonance imaging can also differentiate unusual asymmetric hypertrophy from other pathologic states.


Subject(s)
Cardiomyopathy, Hypertrophic/diagnosis , Adult , Aged , Cardiomyopathy, Hypertrophic/complications , Cardiomyopathy, Hypertrophic/diagnostic imaging , Echocardiography , Female , Humans , Magnetic Resonance Imaging , Male , Middle Aged
18.
Angiology ; 46(9): 863-6, 1995 Sep.
Article in English | MEDLINE | ID: mdl-7661393

ABSTRACT

Lipomatous hypertrophy of the interatrial septum is generally a benign abnormality characterized by deposition of adipose tissue in the interatrial septum, usually extending to the atrial wall and interventricular septum. It is most often detected as an incidental echocardiographic finding. Transesophageal echocardiography can provide additional details, but in this case magnetic resonance imaging proved superior to it in assessing the involvement of other cardiac structures.


Subject(s)
Cardiomegaly/diagnosis , Echocardiography , Heart Neoplasms/diagnosis , Heart Septum/pathology , Magnetic Resonance Imaging , Electrocardiography, Ambulatory , Female , Heart Septum/diagnostic imaging , Humans , Middle Aged
SELECTION OF CITATIONS
SEARCH DETAIL
...