[The evaluation of the adequacy of anesthesia during delivery]. / Otsenka adekvatnosti obezbolivaniia pri rodorazreshenii.

Assessment of anesthesia adequacy in cesarean section carried out under endotracheal narcosis and epidural anesthesia and of the adequacy of analgesia of spontaneous labor by i.m. and i.v. moradol (butorfanol tartrate) has shown that epidural anesthesia provided a more stable status of the autonomic nervous system in the course of cesarean section and that both i.m. and i.v. moradol may be used for spontaneous labor analgesia.

[The pharmacokinetic and pharmacodynamic characteristics of moradol in parturients during obstetrical analgesia]. / Osobennosti farmakokinetiki i farmakodinamiki moradola u rozhenits na protiazhenii obezbolivaniia rodov.

Pharmacokinetic and pharmacodynamic monitoring of moradol (2 mg) given to 16 somatically healthy parturients during analgesia of spontaneous labor has identified 2 groups of patients who significantly differed in kinetic characteristics and in the drug's ability to penetrate through the placenta barrier. At the same time there were no significant differences in autonomic nervous function and central hemodynamics after intravenous moradol analgesia. The newborns from the two groups had identical high scores (8-9). Moradol produced an adequate analgesic effects in all parturients, reaching its peak at min 30-45 and lasting up to 2 hours. There was a high correlation between the plasma drug concentration and pharmacodynamic indices in parturients.

[The validation of the use of Moradol for anesthesia in spontaneous labor]. / Obosnovanie primeneniia moradola dlia obezbolivaniia samoproizvol'nykh rodov.

Pharmacodynamic and pharmacokinetic peculiarities of moradol have been studied during natural delivery. It has been shown that moradol injected both intramuscularly and intravenously in the first period of labour did not inhibit the circulation in the women in labour, had no impact on the course of labour and had no negative effect on the newborn. The use of moradol is recommended for analgesia of natural delivery. A correlation has been established between blood drug concentration and its pharmacodynamic indexes in women.