ABSTRACT
Normally the rat gingival microcirculatory bed is represented by superficial capillaries, postcapillaries, arterioles, and venules of different diameters. The major changes characterizing microcirculation disorders in experimental periodontitis are edema, arteriolar constriction and dilatation, stasis, and thrombosis, which undergo variously directed shifts in different periods of pathological process.
Subject(s)
Gingiva/blood supply , Periodontitis/pathology , Animals , Microcirculation/physiology , Periodontitis/etiology , Rats , Reference ValuesABSTRACT
Grave inflammatory destructive lesions of the periodontium were induced in rats by ligature of canine pericervical area and cyclophosphamide injection. Histological analysis showed regression of inflammatory destructive changes on days 20 and 30 in the majority of animals injected indometaphene after the above experimental exposure but no regression in animals injected no indometaphene.
Subject(s)
Immune Tolerance/drug effects , Periodontitis/drug therapy , Radiation-Protective Agents/therapeutic use , Tamoxifen/analogs & derivatives , Animals , Drug Evaluation, Preclinical , Rats , Tamoxifen/therapeutic useABSTRACT
Light and electron microscopy and spectrophotometry were employed in study of the morphofunctional condition of the hypothalamo-hypophyseal neurosecretory system (HHNS) of intact rats after exposure to stress in injection of substance P. Injection of 12.5 mcg/100g of substance P decelerates the outflow of the neurosecretory substance in intact animals and inhibits the processes of biosynthesis in the neurocytes of the hypothalamic supraoptic nucleus. Injection of substance P prior to exposure of the organism to the stress effects leads to diminution of the HHNS response of them and prevents the development of dystrophic changes in the gastric mucosa.
Subject(s)
Hypothalamo-Hypophyseal System/physiology , Stress, Physiological/physiopathology , Substance P/physiology , Animals , Male , Rats , Rats, Inbred StrainsABSTRACT
A single and double 15 and 30 min exposure to electromagnetic waves of millimetric range (60 GGz, 3 mW/cm2) of a biological active point (acupuncture point) EIII36 of intact male rats and those subjected to stress inhibits the functional activity of hypothalamo-hypophysis neurosecretory system, thyroid gland and cell elements of gastric glands the inhibition being mostly pronounced in animals under stress.