ABSTRACT
Interactions between polymorphonuclear leukocytes (PMNL) and monocytes are changed in inflammatory diseases of the skin; these changes manifest by enhanced stimulation of PMNL migration under the effect of monocytes in psoriasis and by depression of this migration in eczema. In psoriasis HLA-DR-antigens and endogenic monocyte prostaglandins participate in this modulation of cooperative interactions between phagocytic cells, whereas in eczema PMNL superoxide anion takes part in this process. These data may be useful in the diagnosis of inflammatory diseases of the skin and disclose new aspects in the pathogenesis of psoriasis and eczema connected with phagocytic system cells.
Subject(s)
Dermatitis/immunology , Monocytes/immunology , Neutrophils/immunology , Adult , HumansABSTRACT
PHA-induced mononuclear production of lymphokines altering leukocyte migration was studied in patients with psoriasis, mycosis, and scabies. The findings evidence that T-cells synthesize leukocyte migration inhibition factor (LMIF) in mycosis and scabies, whereas in psoriasis they produce both LMIF and leukocyte migration stimulation factor (LMSF). Blood leukocytes of mycosis and scabies patients were more sensitive to LMIF than the cells of psoriasis patients. The 'skin fenestra' cells (granulocytes) of these patients were functionally active only in respect of LMIF, even when mononuclears synthesized LMSF, this evidencing the participation of skin leukocytes of psoriasis patients in blockage of the functional activity of LMSF-producing immunocompetent cells.
Subject(s)
Granulocytes/immunology , Lymphocytes/immunology , Lymphokines/biosynthesis , Skin Diseases/immunology , Skin/immunology , Cell Migration Inhibition , Chemotactic Factors/blood , Dermatomycoses/immunology , Humans , Leukocyte Migration-Inhibitory Factors/biosynthesis , Macrophages , Psoriasis/immunology , Scabies/immunologyABSTRACT
IL-1 and IL-2 interleukins have been studied in patients with diffuse psoriasis en papules et plaques in the stationary stage. The results evidence increased production of IL-1 and its reduced reception by the immunocompetent cells. The lymphocytes have been characterized by a reduced IL-2 synthesis and its lower binding with IL-2-sensitive cells.
Subject(s)
Interleukin-1/blood , Interleukin-2/blood , Psoriasis/blood , Adult , Chronic Disease , Humans , Interleukin-1/biosynthesis , Interleukin-2/biosynthesis , Lymphocytes/metabolism , Middle Aged , Monocytes/metabolism , Receptors, Immunologic/analysis , Receptors, Interleukin-1 , Receptors, Interleukin-2/analysisSubject(s)
Psoriasis/etiology , T-Lymphocytes/immunology , Adolescent , Adult , Cell Migration Inhibition , Combined Modality Therapy , Humans , Lymphocyte Activation/drug effects , Lymphokines/biosynthesis , Middle Aged , Phytohemagglutinins/pharmacology , Psoriasis/immunology , Psoriasis/therapy , T-Lymphocytes/drug effectsSubject(s)
Psoriasis/immunology , Skin/immunology , T-Lymphocytes/immunology , Adolescent , Adult , Cell Migration Inhibition , Female , Humans , In Vitro Techniques , Macrophages/immunology , Male , Middle Aged , Skin Window TechniqueABSTRACT
An increase in the activity of 6-phosphogluconate dehydrogenase, transketolase, ribose-5-phosphatase and intensive conversion of glucose in pentosophosphate pathway in erythrocytes were observed in experimental rat contact dermatitis. Ultrasonic therapy was used (0.2 w/cm2 at impulse regimen of generator) for prevention and treatment of the dermatitis. Treatment of the dermatitis by ultraphonophoresis of sinalar was shown to be a suitable method, which caused the normalization of biochemical and structural processes in skin.
