[Ratio of admixtures of blood group substances and heme pigments in immunoglobulin preparations from different types of raw material]. / Sootnoshenie primesei gruppovykh veshchestv krovi i gempigmentov v preparatakh immunoglobulinov iz razlichnykh vidov syr'ia.

The study of 192 batches of immunoglobulin preparations for the presence of the admixtures of blood group substances and blood pigments has revealed that preparations obtained from abortion and placental blood sera significantly differ from donor immunoglobulins by a greater content of the above admixtures. The absence of correlation between the content of blood pigments and blood group substances in preparations from abortion and placental blood has been significantly demonstrated.

[Intracellular activity and phagocytability of freshly-isolated strains as parameters of the pathogenicity of tuberculosis mycobacteria]. / Vnutrikletochnaia aktivnost' i fagotsitabel'nost' svezhevydelennykh shtammov kak parametry patogennosti mikobakterii tuberkuleza

Phagocytability and the capacity of intracellular multiplication of Mycobacteria tuberculosis isolated from the patients before the treatment and during it (in 1-5 months and later) were studied in the culture of normal peritoneal guinea pig macrophages. A method of quantitative assessment of the capacity to intracellular reproduction of Mycobacteria tuberculosis by determination of the relative activity index in comparison with the standard strain was elaborated. All the cultures of mycobacteria isolated possessed a different extent of intracellular activity and phagocytability. There proved to be no relationship between the intracellular activity indices and the phagocytability of the strains under study. Mycobacteria tuberculosis cultures isolated from the patients during the treatment possessed higher indices of intracellular activity than the initial cultures isolated before the treatment.

[Quantitative evaluation of the effect of depression of Mycobacterium tuberculosis intracellular multiplication under the influence of antibacterial preparations]. / Kolichestvennaia otsenka éffekta podavleniia vnutrikletochnogo razmnozheniia mikobakterii tuberkuleza pod vliianiem antibakterial'nykh preparatov

The use of the average effective dose (ED50) for estimation of the activity of antitubercle drugs against mycobacteria situated inside the cells is proposed. The dose-effect dependence for rifampicin and cycloserin was found. Expedience in the use of the regressive analysis for determination of a number of parameters characterizing qualitatively and quantitatively the effect of the antitubercle drugs on the intracellular multiplication of the bacteria was shown. The programme developed by the authors for the electronic computer "Mir-2" is recommended for this purpose.