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1.
Biull Eksp Biol Med ; 105(6): 713-5, 1988 Jun.
Article in Russian | MEDLINE | ID: mdl-3390591

ABSTRACT

The experiments were carried out on 60 first generation hybrids. Acute systemic "graft-versus-host" reaction (GVHR) was induced in (CBA X C57B1/6) X 60 X 10(6) hybrids by intravenous administration of spleen cells from C57B1/6 parents. Thyroid glands were examined on the 3rd, 10th and 24th days of GVHR. Chronic GVHR was studied in accordance with routine model. (C57B1/6 X DBA/2) hybrids were given 50 X 10(6) spleen cells from DBA/2 parents. Thyroid glands were investigated 6 months after GVHR induction. On the 10th day of GVHR histological examination revealed that follicular-like adenoma tumours with pronounced cellular abnormalities tended to appear in thyroid gland. In a chronic form of GVHR the histological pattern corresponds to that of follicular cancer.


Subject(s)
Adenoma/etiology , Cell Transformation, Neoplastic , Graft vs Host Reaction , Spleen/transplantation , Thyroid Neoplasms/etiology , Adenoma/pathology , Animals , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Thyroid Gland/pathology , Thyroid Neoplasms/pathology , Time Factors
2.
Biull Eksp Biol Med ; 100(11): 595-7, 1985 Nov.
Article in Russian | MEDLINE | ID: mdl-4063510

ABSTRACT

Triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) serum content was measured in mice during systemic "graft-versus-host" reaction (GVHR), using radioimmunoassay. It was demonstrated that on the 3rd day after GVHR induction the levels of these hormones did not differ from the control values. T3 and T4 concentrations and 125I absorption by thyroid gland diminished by day 10. At the same time TSH level remained unchanged. On day 24 after GVHR induction T3 and T4 content was significantly reduced, although TSH concentration exceeded the control value. 125I absorption was enhanced as compared to the value observed on day 10. The data obtained show the vigorous inhibition of thyroid gland function during systemic GVHR.


Subject(s)
Graft vs Host Reaction , Thyroid Gland/physiology , Animals , Iodine/metabolism , Male , Mice , Organ Size , Thyrotropin/blood , Thyroxine/blood , Triiodothyronine/blood
3.
Probl Endokrinol (Mosk) ; 28(2): 57-60, 1982.
Article in Russian | MEDLINE | ID: mdl-7079258

ABSTRACT

The signs of disintegration of hypophyseal-thyroid system function with predominant iodine uptake by thyroid gland cells are detected in the animals during the first 3 days after sarcoma M-1 inoculation. Dissimilar changes in magnesium ion levels are seen in the peripheral blood plasma and thyroid tissue homogenate of the animals with inoculated tumor and injected with non-specific antigenic stimulant.


Subject(s)
Pituitary Gland/physiopathology , Sarcoma, Experimental/physiopathology , Thyroid Gland/physiopathology , Animals , Antigens/immunology , Cattle , Female , Male , Muscles/immunology , Neoplasm Transplantation , Rats , Sarcoma, Experimental/immunology , Thyroid Function Tests , Thyroid Gland/immunology , Time Factors
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