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High level of alpha-synuclein mRNA in peripheral lymphocytes of patients with alcohol dependence syndrome.

Taraskina, A E; Filimonov, V A; Kozlovskaya, Yu A; Morozova, M N; Gaschin, D V; Schwarzman, A L.

Bull Exp Biol Med ; 146(5): 609-11, 2008 Nov.

Article in English | MEDLINE | ID: mdl-19526103

ABSTRACT

The content of mRNA for alpha-synuclein (a key protein of the dopaminergic system) was elevated in the peripheral lymphocytes of patients with alcohol dependence syndrome. Increased level of alpha-synuclein mRNA was not associated with changes in the expression of NR4A2 gene encoding Nurrl, one of the main transcription factors of dopaminergic neurons.

Subject(s)

Alcoholism/genetics , Genetic Predisposition to Disease , Lymphocytes/metabolism , alpha-Synuclein/genetics , Adult , Analysis of Variance , DNA-Binding Proteins/genetics , Humans , Male , Middle Aged , Nuclear Receptor Subfamily 4, Group A, Member 2 , Transcription Factors/genetics

ABSTRACT

Subject(s)

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