ABSTRACT
We analysed the influence of congenital hypothyroidism, diagnosed in the third year of life, on the outcome of pregnancy. We observed the physiological progress of pregnancy and normal development of the foetus. We delivered newborn by caesarean section. We did not observe any disadvantageous influence of congenital hypothyroidism in the mother on newborn status. We analysed the pharmacological substitution and its influence on pregnancy outcome.
Subject(s)
Hypothyroidism/physiopathology , Pregnancy Complications/physiopathology , Adult , Female , Humans , Hypothyroidism/drug therapy , Infant, Newborn , Maternal-Fetal Exchange , Pregnancy , Pregnancy Complications/drug therapy , Pregnancy OutcomeABSTRACT
OBJECTIVES: We present data of three years experience of management and outcome of preterm labour. MATERIALS AND METHODS: The study comprised 335 pregnant women with preterm labour. We analyzed the pharmacological therapy and way of labour. There were two groups of patients: I group--180 patients who had cesarean delivery, II group--155 patients who had vaginal delivery. RESULTS: It has been found 7.54% more cesarean delivery than vaginal delivery of preterm labour.
Subject(s)
Delivery, Obstetric/methods , Delivery, Obstetric/statistics & numerical data , Obstetric Labor, Premature/epidemiology , Adolescent , Adult , Cesarean Section/statistics & numerical data , Decision Making , Female , Humans , Infant, Newborn , Poland/epidemiology , Pregnancy , Pregnancy OutcomeABSTRACT
In this study we took for culture the early-passage human umbilical vein endothelial cells during 12, 24 and 36 hours of hypoxia. To assess the relative contributions of hypoxia, we compared the rates of BrDU incorporation into DNA of proliferating endothelial cells under normoxix and hypoxic conditions. Significant differences in proliferation rates were found only between 24 hours hypoxic group and the control group. Our results support the hypothesis that increased proliferation of human umbilical vein endothelial cells may reflect an adaptation of fetoplacental circulation to hypoxic conditions.
Subject(s)
Antimetabolites/metabolism , Bromodeoxyuridine/metabolism , Endothelium, Vascular/metabolism , Hypoxia/metabolism , Umbilical Veins/metabolism , Antimetabolites/pharmacology , Bromodeoxyuridine/pharmacology , Case-Control Studies , Cell Hypoxia/drug effects , Cells, Cultured , Endothelium, Vascular/drug effects , Female , Humans , In Vitro Techniques , Infant, Newborn , Pregnancy , Time Factors , Umbilical Veins/drug effectsABSTRACT
Our objective was to determine the incidence of nuchal cord and it's possible influence on the nuchal translucency (NT) measurements between 10th and 14th week of gestation. One hundred fourteen singleton pregnancies were studied with transvaginal sonography. Nuchal translucency was measured according to the criteria published by Snijders et al. from the Fetal Medicine Foundation. Nuchal cord was detected with color Doppler flow mapping in 8 of 114 fetuses (7.01%). Mean cord thickness in these fetuses was 1.1 mm (range 0.5-1.4 mm). Mean nuchal translucency with and without umbilical cord were 1.67 mm (SD = 0.67; range: 0.5-3.6) and 1.59 mm (SD = 0.54; range: 0.5-3.0), respectively. The differences were statistically significant (p = 0.0146, Student's t-test for paired observations). We conclude that although relatively infrequent, nuchal cord might have influence on nuchal translucency measurements at the end of the Ist trimester.
Subject(s)
Neck/diagnostic imaging , Neck/embryology , Ultrasonography, Prenatal , Umbilical Cord/diagnostic imaging , Adult , Female , Gestational Age , Humans , Predictive Value of Tests , Pregnancy , Pregnancy Trimester, First , Sensitivity and Specificity , Ultrasonography, Doppler, ColorABSTRACT
The opioid system modulates the growth and development of CNS. Hypoxia increases endogenous opioids significantly. The density and distribution of mu-opioid receptors in MPOA is cyclical and sexually dimorphic. To test the hypothesis that perinatal hypoxia affects the development of the opioid receptor system in fetus brain in both sexes differentially, we performed the following study. We divided 24 pregnant Sprague-Dawley rats to two treatment groups and control group. We exposed one group (CH) to chronic prenatal hypoxia (10.5% O2) continuously 24 h/day and second group (AH) to acute, intermittent hypoxia (9.0% O2) 6 h/day from day E15 to E20. We analyzed the brain regions: CPu, ZG, NA, OT, MMPoA, LMPoA by quantitative autoradiography following incubation with (3H) DAMGO. We didn't notice any significant changes in mu-opioid receptor density between sexes in selected brain regions. We found mu-opioid receptor a significant changes in mu-opioid receptor of all brain regions in female group.
Subject(s)
Disease Models, Animal , Hypoxia, Brain/metabolism , Receptors, Opioid, mu/metabolism , Acute Disease , Animals , Female , Pregnancy , Rats , Rats, Sprague-Dawley , Sex CharacteristicsABSTRACT
The course of multiple pregnancies and multiple fetus labor were analyzed in 111 women delivered in the Department of Obstetrics, School of Medicine in Lublin in the years 1991-1998. It has been found that the most frequent patients were those aged 25-29 coming from the cities and after the infertility treatment. The aim of this research was to characterize twin pregnant patients, and present the outcome of multiple pregnancy. The studies were performed on 67 women from the cities and 44 women from the villages. It is significant that almost 55% pregnant women underwent the cesarean section and their average birth weight was 2490 g. These results indicate that multiple pregnancy is in high risk pregnancy.
Subject(s)
Pregnancy Outcome , Pregnancy, Multiple/statistics & numerical data , Adult , Birth Weight , Cesarean Section/statistics & numerical data , Female , Humans , Infertility, Female/therapy , Maternal Age , Obstetrics and Gynecology Department, Hospital/statistics & numerical data , Poland , Pregnancy , Pregnancy, High-Risk , Retrospective Studies , Risk Factors , Urban HealthABSTRACT
UNLABELLED: The opioid system modulates the growth and development of CNS. Hypoxia increases endogenous opioids significantly. The early development of the opioid receptor system has been reported to be susceptible to perinatal opioid exposure so the developing brain may be influenced by circulating opioids. To test the hypothesis that perinatal hypoxia affects the development of the opioid receptor system in developing brain, we performed the following study. We divided 36 pregnant Sprague-Dawley rats to three treatment groups and control group. We exposed one group (C) to chronic prenatal hypoxia (10.5% O2) continuously 24 h/day and second group (AH) to acute, intermittent hypoxia (9.0% O2) 6 h/day from day E15 to E20. Group of newborns (PH) we exposed to postnatal hypoxia (10.5% O2) from day P2-10. We analyzed the several brain regions: CPu, NA, MMPoA, LMPoA, CA3, VM, AH, Habenula by quantitative autoradiography following incubation with (3H) DAMGO. RESULTS: 1) Chronic prenatal hypoxia decreased mu-receptor binding in all brain regions examined. 2) In contrast, mu-receptor binding following acute, intermittent hypoxia tended to be increased in the several brain regions. 3) Postnatal hypoxia did not change mu-receptor binding in characteristic way. 4) Such receptor changes may be associated with endocrinologic or behavioral abnormalities.
Subject(s)
Brain/embryology , Brain/metabolism , Hypoxia/embryology , Pregnancy, Animal/physiology , Receptors, Opioid, mu/metabolism , Acute Disease , Animals , Binding Sites/physiology , Cell Count , Chronic Disease , Female , Male , Pregnancy , Rats , Rats, Sprague-Dawley/embryologyABSTRACT
This study present a case of a female newborn, gestational age (GA)--27 weeks, birth weight--1020 g (50 percentile), body length--38 cm, head circumference--26 cm, chest circumference--24 cm. The newborn came from the first pregnancy, the amniotic fluid leak was observed for 7 days before delivery resolved by cesarean section. The following consequences of the amniotic band syndrome were observed in the newborn: congenital amputation of lower left limb, congenital amputation of 2nd, 3rd, 4th, 5th fingers in the upper right limb, congenital constricting ring of 1 finger in the upper right limb, congenital amputation of 1st toe in the lower right limb, syndactylism of fingers of upper and lower limbs. The above malformations will be presented and supported by photographic, ultrasound and radiographic documentation.
Subject(s)
Amniotic Band Syndrome/diagnosis , Abnormalities, Multiple , Female , Humans , Infant, Newborn , PregnancyABSTRACT
We described a case with multiple congenital malformations diagnosed at 35 weeks of pregnancy by ultrasound examinations.
Subject(s)
Abnormalities, Multiple/diagnostic imaging , Pregnancy Complications/diagnostic imaging , Adult , Female , Humans , Pregnancy , UltrasonographyABSTRACT
The study was performed to assess prevalence of HPV-DNA infections using the Hybrid Capture System (Vira Papl Vira Typ ). In a group of 228 female patients with Papanicolaou smear grade I and II, high oncogenic risk HPV infections were found in the 15.78% and low oncogenic risk--in 7.01% of the investigated patients. In a group of 324 women with diagnosed CIN, the high oncogenic HPV infection were found in 70.4% of them (CIN I/II-60%, CIN III-87.11%), and the low oncogenic risk HPV infections in 11.1%.
Subject(s)
Papillomaviridae/isolation & purification , Papillomavirus Infections/epidemiology , Tumor Virus Infections/epidemiology , Uterine Cervical Dysplasia/virology , DNA, Viral/analysis , Female , Humans , Papanicolaou Test , Papillomavirus Infections/diagnosis , Poland/epidemiology , Prevalence , Risk Assessment , Tumor Virus Infections/diagnosis , Vaginal SmearsABSTRACT
We have retrospectively analyzed 77 cases of pregnant patients with cervical incompetence in which we performed cervical cerclage. These cases were 0.65% of all deliveries. The age was 20-41 years (mean 28.5). They were in second or third pregnancy. 62 women delivered by vaginal way and 15 by cesarean section. Only 5 newborn had small weight for age. We discussed our results with data from other authors.
Subject(s)
Uterine Cervical Incompetence/surgery , Adult , Delivery, Obstetric , Female , Humans , Infant, Low Birth Weight , Infant, Newborn , Parity , Pregnancy , Pregnancy Outcome , Retrospective StudiesABSTRACT
Caesarean sections complicated with peritonitis were analysed in a period of 10 years. In the whole group of 2238 caesarean sections done in the years 1977-1986 peritonitis developed in 8 cases (0.36%). In this group total or supracervical hysterectomy was done between the 4th and the 7th days of puerperium. Diagnostic difficulties in puerperal peritonitis and advantages of early surgical intervention for saving the life of the women in puerperium are stressed.
Subject(s)
Cesarean Section/adverse effects , Peritonitis/epidemiology , Puerperal Infection/epidemiology , Adult , Female , Humans , Incidence , Peritonitis/diagnosis , Peritonitis/surgery , Puerperal Infection/diagnosis , Puerperal Infection/surgeryABSTRACT
The study was carried out on 48 human placentas perfused in vitro. Betamethasone was administered into the arterial systems in the following single doses: 0.4 mg, 2 mg and 10 mg. The authors found a highly significant or statistically insignificant decreased glucose consumption after administering each dose of betamethasone and at all times of the experiment. The phenomenon of a decrease in glucose consumption was attributed to an increased gluconeogenesis and releasing glucose from placental glycogen. The action of betamethasone consisting in supplying an increased amount of glucose is of great importance in the process of maturing fetal lungs in the uterus and in states threatening the fetus.
Subject(s)
Betamethasone/pharmacology , Glucose/pharmacokinetics , Placenta/metabolism , Female , Humans , In Vitro Techniques , Pregnancy , ReperfusionABSTRACT
The study was carried out on 48 human placentas perfused in vitro. Betamethasone was administered into the arterial system in the following single doses: 0.4 mg, 2 mg, 10 mg. It was found that betamethasone decreases the pressure of perfusion in different ways depending on the dose. A statistically significant decrease in perfusion pressure was observed in 30th minute of the experiment after administering 2 mg while a dose of 10 mg induced a significant perfusion pressure in 30th and 60th minute of the experiment. The relaxation of the blood vessels of the placenta under the influence of betamethasone was attributed to the action of dopamine on the dopaminergic receptors of the vessels and glucocorticoids modifying this action. The results of the experiments point to a positive action of betamethasone on the blood vessels of human placenta.
