Dual stage fiber amplifier operating near 3 µm with milijoule-level, sub-ns pulses at 5 W.

We report a 2800 nm Er3+-doped fluoride fiber amplifier that delivers 1 mJ pulses with an average power of 5 W and pulse duration of 1 ns at 5 kHz repetition rate. To the best of our knowledge, this is the highest pulse energy achieved from a fluoride-fiber-based system operating near 3 µm, and the W-level average power and short pulse lengths make the system a promising tool for biomaterials processing.

High-energy picosecond pulses from a 2850 nm fiber amplifier.

We report the demonstration of a 2850 nm diode-pumped Ho3+, Pr3+ co-doped fluoride fiber amplifier that delivers pulses with an average power of 2.45 W, 122 µJ energy, and 500 ps duration at a repetition rate of 20 kHz. To the best of our knowledge, the average power and pulse energy are the highest to be obtained from a sub-nanosecond fiber source operating in the 3 µm spectral region. The amplifier is seeded by an optical parametric generation source and is pumped around 915 nm using widely available InGaAs laser diodes.

Ultrafast mid-IR laser scalpel: protein signals of the fundamental limits to minimally invasive surgery.

Lasers have in principle the capability to cut at the level of a single cell, the fundamental limit to minimally invasive procedures and restructuring biological tissues. To date, this limit has not been achieved due to collateral damage on the macroscale that arises from thermal and shock wave induced collateral damage of surrounding tissue. Here, we report on a novel concept using a specifically designed Picosecond IR Laser (PIRL) that selectively energizes water molecules in the tissue to drive ablation or cutting process faster than thermal exchange of energy and shock wave propagation, without plasma formation or ionizing radiation effects. The targeted laser process imparts the least amount of energy in the remaining tissue without any of the deleterious photochemical or photothermal effects that accompanies other laser wavelengths and pulse parameters. Full thickness incisional and excisional wounds were generated in CD1 mice using the Picosecond IR Laser, a conventional surgical laser (DELight Er:YAG) or mechanical surgical tools. Transmission and scanning electron microscopy showed that the PIRL laser produced minimal tissue ablation with less damage of surrounding tissues than wounds formed using the other modalities. The width of scars formed by wounds made by the PIRL laser were half that of the scars produced using either a conventional surgical laser or a scalpel. Aniline blue staining showed higher levels of collagen in the early stage of the wounds produced using the PIRL laser, suggesting that these wounds mature faster. There were more viable cells extracted from skin using the PIRL laser, suggesting less cellular damage. ß-catenin and TGF-ß signalling, which are activated during the proliferative phase of wound healing, and whose level of activation correlates with the size of wounds was lower in wounds generated by the PIRL system. Wounds created with the PIRL systsem also showed a lower rate of cell proliferation. Direct comparison of wound healing responses to a conventional surgical laser, and standard mechanical instruments shows far less damage and near absence of scar formation by using PIRL laser. This new laser source appears to have achieved the long held promise of lasers in minimally invasive surgery.

Laser selective cutting of biological tissues by impulsive heat deposition through ultrafast vibrational excitations.

Mechanical and thermodynamic responses of biomaterials after impulsive heat deposition through vibrational excitations (IHDVE) are investigated and discussed. Specifically, we demonstrate highly efficient ablation of healthy tooth enamel using 55 ps infrared laser pulses tuned to the vibrational transition of interstitial water and hydroxyapatite around 2.95 microm. The peak intensity at 13 GW/cm(2) was well below the plasma generation threshold and the applied fluence 0.75 J/cm(2) was significantly smaller than the typical ablation thresholds observed with nanosecond and microsecond pulses from Er:YAG lasers operating at the same wavelength. The ablation was performed without adding any superficial water layer at the enamel surface. The total energy deposited per ablated volume was several times smaller than previously reported for non-resonant ultrafast plasma driven ablation with similar pulse durations. No micro-cracking of the ablated surface was observed with a scanning electron microscope. The highly efficient ablation is attributed to an enhanced photomechanical effect due to ultrafast vibrational relaxation into heat and the scattering of powerful ultrafast acoustic transients with random phases off the mesoscopic heterogeneous tissue structures.