ABSTRACT
The in vitro activity of netilmicin was compared to gentamicin, tobramycin and amikacin against 461 strains of glucose fermenting and nonfermenting bacteria. The minimum inhibitory concentrations of netilmicin, gentamicin and tobramycin against the majority of Enterobacteriaceae, Staphylococcus and Streptococcus were quite similar. Gentamicin, however, was approximately fourfold more active against strains of S. marcescens. Amikacin was the most effect antibiotic against strains of fermenting and nonfermenting bacilli resistant to at least one aminoglycoside. Many gentamicin-resistant species of nonfermenting bacilli, however, remain highly resistant to all four aminoglycosides tested.
Subject(s)
Amikacin/pharmacology , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Gentamicins/pharmacology , Kanamycin/analogs & derivatives , Netilmicin/pharmacology , Tobramycin/pharmacology , Drug Resistance, Microbial , Enterobacteriaceae/drug effects , Fermentation , Glucose/metabolism , Microbial Sensitivity Tests , Pseudomonas/drug effects , Staphylococcus/drug effects , Streptococcus/drug effectsABSTRACT
The in vitro inhibitory activity of rosamicin and erythromycin against 283 strains of nonfermenting, gram-negative bacilli was determined by using a broth dilution procedure. Rosamicin demonstrated greater activity than erythromycin against most strains tested. A number of species demonstrated significantly lower minimum inhibitory concentrations to rosamicin and would fall within the therapeutic range of the drug based on current pharmacological data.
