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Cogn Neuropsychiatry ; 10(2): 137-52, 2005 Mar.
Article in English | MEDLINE | ID: mdl-16571457

ABSTRACT

INTRODUCTION: In past research it has been demonstrated that when performing a visual search task with either one or multiple (4, 7 or 10) stimuli displayed, patients with schizophrenia demonstrate slow response times (RTs) in the display size of one, target-absent (one-absent) condition. The goals of the present investigation were to replicate this effect, and to gain an understanding of the underlying cognitive operations by comparing display-size switch to display-size repeat trials. METHODS: In two experiments, patients and controls performed a visual search task with either one or four stimuli displayed. In Experiment 1 (one block with mixed switch and repeat trials), RT for display-size switch trials was compared to RT from display-size repeat trials. In Experiment 2, the display-size one and display-size four conditions were run in separate, homogeneous blocks. RESULTS: The results demonstrate that the one-absent slowing effect was eliminated on repeat trials, regardless of whether the switch and repeat trials were mixed or presented in separate blocks. CONCLUSIONS: This set of results suggests that a combination of cueing and switching effects may underlie the one-absent slowing observed in patients, such that switching to the one-absent condition is difficult due to insufficient cueing of the relevant cognitive operations. This visual search paradigm is an excellent candidate for inclusion in the development of a neurocognitive profile specific to schizophrenia.

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