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2.
J Small Anim Pract ; 41(7): 308-11, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10976626

ABSTRACT

A prospective study was undertaken to compare intravenous tetracosactrin at doses of 5 microg/kg and 250 microg for diagnosing hyperadrenocorticism in dogs. Both healthy dogs and dogs with pituitary-dependent hyperadrenocorticism were evaluated with the two doses of the drug, and serum cortisol concentrations were compared at 60 minutes post-stimulation. Some of the dogs had additional samples taken at 90 and 120 minutes. For four dogs with hyperadrenocorticism, timed samples were also obtained at 150, 180 and 240 minutes post-injection. Cortisol concentrations 60 minutes after stimulation with either 5 microg/kg or 250 microg intravenous tetracosactrin were similar for both healthy dogs and dogs with hyperadrenocorticism. The lower dose can therefore be used for diagnosing hyperadrenocorticism in dogs.


Subject(s)
Adrenocortical Hyperfunction/veterinary , Cosyntropin , Dog Diseases/diagnosis , Dogs/blood , Hydrocortisone/blood , Adrenocortical Hyperfunction/diagnosis , Animals , Cosyntropin/pharmacokinetics , Dose-Response Relationship, Drug , Injections, Intravenous , Prospective Studies , Random Allocation , Reference Values , Time Factors
3.
J Am Vet Med Assoc ; 216(1): 51-4, 2000 Jan 01.
Article in English | MEDLINE | ID: mdl-10638318

ABSTRACT

OBJECTIVE: To characterize rib, intrathoracic, and concurrent orthopedic injuries, and prognosis associated with traumatic rib fracture in cats. DESIGN: Retrospective study. ANIMALS: 75 cats. PROCEDURE: Medical records from January 1980 to August 1998 were examined for cats with traumatic rib fracture. Signalment, cause of trauma, interval from trauma to evaluation at a veterinary teaching hospital, referral status and date, method of diagnosis, duration of hospitalization, number and location of rib fractures, presence of flail chest, costal cartilage involvement, intrathoracic and concurrent orthopedic injury, and clinical outcome were reviewed. RESULTS: Median age was 3 years. Twenty-five (58%) cats with reported cause of trauma were injured by interaction with another animal. Forty-seven (78%) cats that were treated survived. Cats that died had a median duration of hospitalization of < 1 day. Ten (13%) cats had flail chest. Sixty-five (87%) cats had intrathoracic injury (median, 2 injuries). Nine (100%) cats without detected intrathoracic injury that were treated survived. Thirty-five (47%) cats had concurrent orthopedic injury. Cats with flail chest, pleural effusion, or diaphragmatic hernia were significantly more likely to die than cats without each injury. CONCLUSIONS AND CLINICAL RELEVANCE: Traumatic rib fracture in cats is associated with intrathoracic and concurrent orthopedic injury. Aggressive treatment of cats with traumatic rib fracture is warranted, because the prognosis is generally favorable. Diagnosis and treatment of intrathoracic injury associated with traumatic rib fracture in cats should precede management of concurrent orthopedic injury.


Subject(s)
Cats/injuries , Rib Fractures/veterinary , Wounds and Injuries/veterinary , Animals , Female , Flail Chest/complications , Flail Chest/therapy , Flail Chest/veterinary , Hernia, Diaphragmatic/complications , Hernia, Diaphragmatic/veterinary , Male , Multivariate Analysis , Pleural Effusion/complications , Pleural Effusion/veterinary , Prognosis , Radiography, Thoracic/veterinary , Retrospective Studies , Rib Fractures/complications , Rib Fractures/therapy , Surveys and Questionnaires , Wounds and Injuries/complications , Wounds and Injuries/therapy
4.
J Am Vet Med Assoc ; 214(5): 670-2, 1999 Mar 01.
Article in English | MEDLINE | ID: mdl-10088016

ABSTRACT

Eight cats with visceral or cutaneous hemangiosarcoma were evaluated, and unusual metastatic and clinicopathologic behavior was evident in each. Cutaneous hemangiosarcoma is generally believed to be locally aggressive and slow to metastasize. These 8 cats with cutaneous hemangiosarcoma, however, developed metastatic disease after initial surgical resection; only 1 had local regrowth of the tumor. All cats with visceral hemangiosarcoma had metastasis at the time of diagnosis, which is consistent with cats of other reports. Three of 8 cats had evidence of disseminated intravascular coagulation, including increased prothrombin time and partial thromboplastin time, decreased number of platelets, and anemia. These potential complications need to be considered when planning diagnostic and treatment protocols.


Subject(s)
Abdominal Neoplasms/veterinary , Cat Diseases/pathology , Hemangiosarcoma/veterinary , Skin Neoplasms/veterinary , Abdominal Neoplasms/blood , Abdominal Neoplasms/pathology , Anemia/etiology , Anemia/veterinary , Animals , Blood Coagulation Disorders/etiology , Blood Coagulation Disorders/veterinary , Cat Diseases/blood , Cats , Disseminated Intravascular Coagulation/veterinary , Eye Neoplasms/secondary , Eye Neoplasms/veterinary , Female , Hemangiosarcoma/blood , Hemangiosarcoma/secondary , Lymphatic Metastasis , Male , Mediastinal Neoplasms/blood , Mediastinal Neoplasms/pathology , Mediastinal Neoplasms/veterinary , Mesentery , Nose Neoplasms/blood , Nose Neoplasms/pathology , Nose Neoplasms/veterinary , Peritoneal Neoplasms/blood , Peritoneal Neoplasms/pathology , Peritoneal Neoplasms/veterinary , Skin Neoplasms/blood , Skin Neoplasms/pathology , Splenic Neoplasms/blood , Splenic Neoplasms/pathology , Splenic Neoplasms/veterinary
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