ABSTRACT
The drugs and techniques used in contemporary anaesthesia may provoke numerous side effects, including cardiac rhythm disturbances. The prolongation of the repolarization time, reflected by the QT interval in a surface electrocardiogram, is one of the mechanisms that lead to the occurrence of arrhythmias. In the paper, we present the primary mechanism that is responsible for QT interval prolongation and subsequent torsade de pointes ventricular tachycardia. The influence of anesthetics, regional anesthesia and perioperative supportive therapy on cardiac repolarization is described.
Subject(s)
Anesthetics/adverse effects , Long QT Syndrome/chemically induced , Tachycardia, Ventricular/chemically induced , Torsades de Pointes/chemically induced , Adolescent , Adult , Aged , Anesthesia, Conduction/adverse effects , Anesthesia, General/adverse effects , Child , Child, Preschool , Electrocardiography/drug effects , Female , Humans , Infant , Long QT Syndrome/physiopathology , Long QT Syndrome/therapy , Male , Middle Aged , Perioperative Care , Tachycardia, Ventricular/physiopathology , Tachycardia, Ventricular/therapy , Torsades de Pointes/physiopathology , Torsades de Pointes/therapy , Young AdultABSTRACT
The polymorphism of the D1S80 locus has been analyzed in a population sample of 208 unrelated individuals in the Southeast Poland and 103 mother/child pairs. PCR amplified alleles were separated by a vertical discontinuous polyacrylamide gel electrophoresis system. Nineteen different alleles and 52 phenotypes could be distinguished. The alleles 18 (f = 0.267) and 24 (f = 0.300) were most common in Poland. D1S80 genotype frequencies of Poland population do not deviate from Hardy-Weinberg equilibrium. All mother/child pairs shared at least one D1S80 allele.
