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1.
J Cancer Res Clin Oncol ; 147(6): 1763-1771, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33219855

ABSTRACT

PURPOSE: Uveal melanoma (UM) is an orphan cancer of high unmet medical need. Current patterns of care and surveillance remain unclear as they are situated in an interdisciplinary setting. METHODS: A questionnaire addressing the patterns of care and surveillance in the management of patients with uveal melanoma was distributed to 70 skin cancer centers in Austria, Germany and Switzerland. Frequency distributions of responses for each item of the questionnaire were calculated. RESULTS: 44 of 70 (62.9%) skin cancer centers completed the questionnaire. Thirty-nine hospitals were located in Germany (88.6%), three in Switzerland (6.8%) and two in Austria (4.5%). The majority (68.2%) represented university hospitals. Most patients with metastatic disease were treated in certified skin cancer centers (70.7%, 29/41). Besides, the majority of patients with UM were referred to the respective skin cancer center by ophthalmologists (87.2%, 34/39). Treatment and organization of follow-up of patients varied across the different centers. 35.1% (14/37) of the centers stated to not perform any screening measures. CONCLUSION: Treatment patterns of patients with uveal melanoma in Germany, Austria and Switzerland remain extremely heterogeneous. A guideline for the treatment and surveillance is urgently needed.


Subject(s)
Aftercare , Melanoma/therapy , Monitoring, Physiologic , Practice Patterns, Physicians'/statistics & numerical data , Uveal Neoplasms/therapy , Aftercare/methods , Aftercare/statistics & numerical data , Austria/epidemiology , Cross-Sectional Studies , Follow-Up Studies , Germany/epidemiology , Health Services Needs and Demand/statistics & numerical data , Humans , Mass Screening/methods , Mass Screening/statistics & numerical data , Melanoma/epidemiology , Melanoma/pathology , Monitoring, Physiologic/methods , Monitoring, Physiologic/statistics & numerical data , Neoplasm Metastasis , Neoplasm Recurrence, Local/epidemiology , Population Surveillance/methods , Referral and Consultation/standards , Referral and Consultation/statistics & numerical data , Skin Neoplasms/epidemiology , Skin Neoplasms/pathology , Skin Neoplasms/therapy , Surveys and Questionnaires , Switzerland/epidemiology , Uveal Neoplasms/epidemiology , Uveal Neoplasms/pathology
2.
Acta Derm Venereol ; 95(3): 329-31, 2015 Mar.
Article in English | MEDLINE | ID: mdl-24995552

ABSTRACT

Pityriasis rubra pilaris (PRP) is an uncommon cutaneous disease with disorder of keratinisation. Up to now, systemic retinoids like acitretin or isotretinoin seem to be the most effective therapeutic agents. However, no large trials on this rare disease have been published and no standardised treatment has been established so far. Recently, single case reports demonstrate beneficial effects of alitretinoin (9-cis retinoic acid) in patients with PRP. We performed a retrospective observational analysis of type I adult-onset patients with PRP (n = 5) treated with systemic alitretinoin in our department. Alitretinoin was highly effective in the treatment of PRP in 4 of 5 cases. PASI score was reduced significantly in the alitretinoin responders. We assume that alitretinoin could serve as an additional effective systemic treatment option for type I adult-onset PRP.


Subject(s)
Keratolytic Agents/therapeutic use , Pityriasis Rubra Pilaris/drug therapy , Tretinoin/therapeutic use , Aged , Aged, 80 and over , Alitretinoin , Female , Humans , Male , Middle Aged , Pityriasis Rubra Pilaris/diagnosis , Remission Induction , Retrospective Studies , Treatment Outcome
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