ABSTRACT
The data of HLA-haplotyping were used as an allele marker controlling hereditary hemochromatosis in 23 patients with beta-thalassemia. The results obtained have permitted a conclusion that hemosiderosis in patients with beta-thalassemia may be caused by association of beta-thalassemia gene with hereditary hemochromatosis. Early diagnosis of hyperferremia is of great prognostic importance as the adequate treatment timely conducted can prevent the development of irreversible changes in the patients.
Subject(s)
HLA Antigens/genetics , Hemochromatosis/complications , Hemosiderosis/etiology , Thalassemia/complications , Adolescent , Adult , Child , Child, Preschool , Genetic Linkage/genetics , Genotype , HLA-A3 Antigen/genetics , HLA-B Antigens/genetics , HLA-B14 Antigen , HLA-B35 Antigen/genetics , HLA-B7 Antigen/genetics , Hemochromatosis/genetics , Hemosiderosis/genetics , Humans , Male , Middle Aged , Pedigree , Thalassemia/geneticsSubject(s)
Blood Donors , Chromosomes, Human, Pair 6 , Genes , Hemochromatosis/genetics , Heterozygote , Urban Population , Adolescent , Adult , Female , Genetic Carrier Screening , HLA Antigens/analysis , HLA Antigens/genetics , Hemochromatosis/blood , Humans , Male , Moscow , Risk FactorsSubject(s)
Hemochromatosis/genetics , Adolescent , Adult , Aged , Child , Female , Hemochromatosis/diagnosis , Humans , Male , Middle Aged , PedigreeABSTRACT
To determine the HLA-phenotype of a potential donor of pancreatic islet cells, use was made of lymphocytes from 18-25-week-old human fetuses. The HLA-phenotype was clearly established in 39 out of 52 cases. In 13 cases, the authors failed to reveal histocompatibility antigens because of low viability of lymphocytes. The relationship was ascertained between the detectability of HLA-antigens in fetal donors and cytophysiological characteristics of islet cell cultures prepared from the pancreas.