ABSTRACT
Radiometry of distribution of drugs introduced with soft contact lenses (with 40 and 70% humor content and thickness of 0.2 and 0.7 mm) in the ocular cavity was carried out to compare this mode of drug administration with the traditional methods. The maximal concentrations of the drugs in the anterior chamber humor and in the vitreous body were attained by using saturated highly hydrophilic 0.7 mm thick contact lenses. The drug content in the anterior chamber of the eye upon such a mode of administration was higher than after injection and much higher than after instillation.
Subject(s)
Contact Lenses, Hydrophilic , Pharmaceutical Preparations/administration & dosage , Animals , Anterior Chamber/metabolism , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/pharmacokinetics , Anti-Inflammatory Agents/administration & dosage , Anti-Inflammatory Agents/pharmacokinetics , Atropine/administration & dosage , Atropine/pharmacokinetics , Dexamethasone/administration & dosage , Dexamethasone/pharmacokinetics , Gentamicins/administration & dosage , Gentamicins/pharmacokinetics , Humans , In Vitro Techniques , Mydriatics/administration & dosage , Mydriatics/pharmacokinetics , Rabbits , Vitreous Body/metabolismABSTRACT
The in vitro kinetics (specifically, absorption and desorption) of drugs belonging to various pharmacological groups (atropine sulfate, gentamicin sulfate, dexamethasone, lecozyme, and poludan) in soft contact lenses (low-hydrophilic with 40% aqueous content and highly hydrophilic with 74% aqueous content. 0.2 and 0.7 mm thick) was studied by radiometry, as were the effects of chemical structure of a drug, hydrophilic properties and thickness of soft contact lenses, and temperature of solution on these processes.
