1.
Russ Chem Bull
; 71(8): 1687-1700, 2022.
Article
in English
| MEDLINE
| ID: mdl-36185466
ABSTRACT
The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity.
2.
Bioorg Med Chem
; 25(1): 91-99, 2017 01 01.
Article
in English
| MEDLINE
| ID: mdl-27776888
ABSTRACT
We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.