ABSTRACT
Alterations on dynamics of excretion with urine of dopamine, noradrenaline, vanilylmandelic acid and N1-methyl nicotinamide were detected in 7-11 years old children with mental insufficiency accompanied by effective component of the hyperdynamic syndrome in the course of treatment with sidnocarb and sonapax. Sidnocarb was shown to alter positively the excretion of noradrenaline and sonapax--that of N1-methyl nicotinamide. Clinical features of the hyperdynamic syndrome should be taken into consideration in prescription of drug therapy.
Subject(s)
Attention Deficit Disorder with Hyperactivity/metabolism , Biogenic Amines/metabolism , Attention Deficit Disorder with Hyperactivity/drug therapy , Attention Deficit Disorder with Hyperactivity/urine , Biogenic Amines/urine , Child , Female , Humans , Male , Psychotropic Drugs/therapeutic use , Sydnones/therapeutic useABSTRACT
Fifty children aged 7 to 11 with the hyperdynamic syndrome were under treatment. Sydnocarb proved effective only in cases which did not involve prominent emotional-volitional disorders. Symptom reduction was primarily concerned with motor disinhibition and distractibility. The drug had no effect in treating hyperdynamic syndrome with psychopathology.
Subject(s)
Attention Deficit Disorder with Hyperactivity/drug therapy , Oxadiazoles/therapeutic use , Psychotropic Drugs/therapeutic use , Sydnones/therapeutic use , Attention Deficit Disorder with Hyperactivity/diagnosis , Attention Deficit Disorder with Hyperactivity/psychology , Child , Drug Evaluation , Electroencephalography , Humans , Neurologic Examination , Psychopathology , Wechsler ScalesABSTRACT
Fifty-five children with a mild degree of intellectual retardation leading to school disadaptation have been examined, using clinical and neuropsychological methods of investigation. Depending on the underlying disorder, 2 groups of children were identified: with local cortical abnormalities and with the hyperdynamic syndrome. The question is discussed about correlation between dysfunction of definite cerebral structures and disorders of active attention, motor disinhibition, affective and intellectual disorders. The authors specify new possibilities of the differential diagnosis of mild degrees of intellectual insufficiency with the help of a clinico-neuropsychological analysis of the syndrome which makes it possible to approach medico-pedagogical correction of such states from the pathogenetic viewpoint.
