1.
Farmakol Toksikol
; 43(4): 433-9, 1980.
Article
in Russian
| MEDLINE
| ID: mdl-6160054
Subject(s)
Cardiotonic Agents/pharmacology , Coronary Disease/drug therapy , Heart/drug effects , Molecular Biology , Adenosine Triphosphate/metabolism , Animals , Cardiotonic Agents/therapeutic use , Cell Membrane/drug effects , Coronary Disease/metabolism , DNA/metabolism , Energy Metabolism/drug effects , Mitochondria, Heart/drug effects , Mitochondria, Heart/radiation effects , Oxidation-Reduction/drug effects , RNA/metabolism , Ultraviolet Rays , Vitamin E/pharmacology , Vitamin E/therapeutic use
2.
Farmakol Toksikol
; 42(3): 251-4, 1979.
Article
in Russian
| MEDLINE
| ID: mdl-446704
ABSTRACT
The effect of preliminary administration of alpha-tocopherol acetate (1 mg/kg) and sodium selenite (1 mg/kg) on RNA synthesis rate and changes in the macroergic content in ischemic myocardium was studied. It was shown to be conducive to ATP level maintenance after 30- and 60-minute heart ischemia. A statistically significant accumulation of RNA by the myocardium following I-hour ischemia as well as this polynucleotide synthesis activation were recorded. Preservation of the energetic resources by the cell along with RNA metabolism returning to normal contributes to inhibiting the emergence of irreversible cell damage and increases regenerative potentialities of the myocardium.