Post-COVID-19 psychosis: Cotard's syndrome and potentially high risk of harm and self-harm in a first-onset acute and transient psychotic disorder after resolution of COVID-19 pneumonia.

AIM: This report aims to illustrate the possibility of an acute onset of psychosis after COVID-19 infection in a patient without previous history of psychiatric disorders and to highlight the need for early screening and intervention in such cases. METHODS: Clinical presentation of a case, followed by clinical discussion and literature review of the effect of the new coronavirus SARS-CoV-2 and its impact on mental health in terms of neuropsychiatric conditions. RESULTS: We present a case of acute and transient psychotic disorder following complete recovery of COVID-19 bilateral pneumonia. The patient has no prior psychiatric history and presents with acute onset, disorganized behaviour, Cotard's delusion and a potentially high risk of psychotic homicide and suicide. CONCLUSION: Early intervention and treatment with antipsychotic medication are of crucial importance for the effective treatment and complete recovery of these patients.