Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.

Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used live bacterial vaccine. However, limited information is available correlating route and dose of vaccination and induction of specific T cell responses with protection against tuberculosis. We compared efficacy of oral and systemic vaccination and correlated vaccine-induced T cell responses with protection in experimental tuberculosis of mice. After oral and systemic vaccination, we observed profound differences in persistence and dissemination of BCG and frequencies and location of specific IFN-gamma-secreting CD4(+) and CD8(+) T cells. Yet, both vaccination routes caused comparable levels of protection against aerosol challenge with Mycobacterium tuberculosis. Protection correlated best with rapid accumulation of specific CD8(+) T cells in infected tissues of challenged mice. In contrast, specific IFN-gamma production by CD4(+) T cells reflected the load of M. tuberculosis rather than the strength of protection. Our data question the measurement of IFN-gamma secretion by CD4(+) T cells and emphasize the need for new biomarkers for evaluation of tuberculosis vaccine efficacies.

[Effects of photo-acoustic stimulation combined with hypnotherapy on saliva secretion. A pilot study]. / A fény-hang stimulációval kombinált hipnoterápia hatásai a nyálszekrécióra. Elózetes klinikai vizsgálatok.

Effect of photo-acoustic stimulation on the flow rate and protein concentration of whole saliva was investigated. 10 medical students' and 11 edentulous patients' salivary volume and protein concentrations were measured before, during, and after stimulation. The flow rate of the students' group was significantly higher (p < or = 0.01) before and after the treatment, whereas the protein concentration was significantly lower (p < or = 0.05) before, during and after treatment comparing to the patients' group. The flow rate of the students' groups significantly decreased during stimulation (p < or = 0.05). Salivary protein concentration of the students' group significantly increased (p < or = 0.05) after stimulation. There were no significant changes in the group of patients. Repeated stimulation combined with hypnotic relaxation was used in the case of 4 psychosomatic patients. Resting salivary flow and protein concentration significantly increased in 2 cases (p < or = 0.05) as a result of the therapy.

German noun plurals: a challenge to the dual-mechanism model.

In this article, the authors test one of the central claims of the Dual-Mechanism Model (Pinker and Prince, 1994), that is, that regular inflection equals default inflection. Based on results from an elicitation task with eight agrammatic Broca's aphasics and a lexical decision task with unimpaired subjects, the authors show that this assumption is not borne out. Their data on German plural inflection rather indicate that regular inflection is not necessarily identical to default inflection. To capture the German data, they have to assume regular but input-restricted inflection besides regular default inflection.

Inflectional morphology in German Williams syndrome.

In a recent paper, Clahsen and Almazan (1998) reported a dissociation between unimpaired regular and impaired irregular past tense morphology in English Williams syndrome (WS). Our aim is to investigate whether these findings carry over to another language with different morphological systems. We present data on regular and irregular participles and noun plurals from 2 German WS subjects and 10 controls matching in mental age. For noun plurals, regular morphology is intact in WS, whereas irregular forms are impaired. A similar dissociation is observed for participles: while regular inflection is unimpaired, WS subjects, unlike controls, apply the regular suffix incorrectly to frequent irregular verbs. We discuss our findings against the current debate between connectionist and dualistic approaches to the language faculty.