[THE WAYS TO IMPROVE SURGICAL TREATMENT OF PILONIDAL DISEASE].

Analysis of the surgical treatment results in 54 patients, suffering pilonidal disease in 2011 - 2013 yrs, was done. Introduction of procedure, proposed in the clinic, for the operative wound closure after pilonidal disease surgical treatment have promoted the postoperative morbidity rate reduction and the patients treatment results improvement. A summation of a two-layered horizontal suture on different levels of subcutaneous layer and of vertical knot cutaneous sutures have guaranteed the possibility of the wound healing by a primary tension fashion, without durable filling of the wound defect with granulations.

[APPLICATION OF MINIINVASIVE INTERVENTIONS UNDER ULTRASONOGRAPHIC CONTROL FOR NONPARASITIC HEPATIC CYSTS].

The results of treatment of 21 patients, suffering nonparasitic hepatic cysts, using laparoscopic draining and puncture under ultrasonographic control, were analyzed. Minimal traumaticity of the intervention, absence of necessity to apply general anesthesia, low rate of postoperative morbidity (7.1%), reduction of duration of the patients stationary treatment down to (3.3 ± 0.61) days, reduction of economic wastes on the treatment constitute the advantages of such method.

[Dependence of the operation stress degree from the kind of operative intervention for an acute cholecystitis in the patients with high operative-anesthesiological risk].

The results of comparison between the operation stress degree in various kinds of surgical interventions, performed for an acute cholecystitis, using determination of cortizol, prolactin and glucose content before the operation, intraoperatively and postoperatively in 50 patients, are adduced. There was established, that the largest (in 5.3 times) and the most durable (more than 24 hours) intr erative raising of the cortizol level in the blood serum was noted in patients, to whom open cholecystectomy (OCH) was done, and the minimal (in 2.2 times) and the least durable (up to 1 hour)--while performing transcutaneous transhepatic draining (TTD) of gallbladder under ultrasonographic control. While performance of laparoscopic cholecystectomy (LCH) there was noted the most pronounced intraoperative raising of prolactin level (in 3.6 times) and more rapid its lowering (during 24 hours) in comparison with such while the OCH performance (during 72 hours). In TTD there was observed the minimal intraoperative inhancing of the prolactin level (in 2.3 times) and its duration (during 1 hour) postoperatively. The above mentioned have witnessed, that while TTD of gallbladder performance stimulation of the anterior hypophysis is significantly lesser, than while LCH and OCH.

[Intensive therapy of uncontrolled internal hemorrhage before the surgical hemostasis conduction in polytrauma].

The traumatic disease course was studied up in 287 injured persons with polytrauma and shock, 195 (67.9%) of them were admitted to hospital with continuing internal (noncontrolled) hemorrhage. The traumatic disease outcome was analyzed depending on the medical aid volume, delivered on prehospital stage, its duration, the arterial pressure level while admittance to the hospital and the blood loss volume. Maximal lethality was noted while nonconducting of infusion therapy on prehospital stage, as well as in aggressive infusion conduction with early normalization of arterial pressure; optimal outcome was achieved using intensive therapy before surgical hemostasis conduction while application of the hypotensive resuscitation regimen with minimal tissue perfusion and in systolic arterial pressure in the 80-90 mm Hg range.

[Peculiarities of the blood microcirculation in the anterior abdominal wall in patients with excessive body mass].

Investigation was conducted, using laser Doppler flowmetry (LDF) with the help of LAKK-02 analizator, with the objective to improve the results of surgical treatment and prophylaxis of complications in the postoperative wound healing in patients, suffering concomitant obesity. Characteristic disorders of microcirculation in soft tissues of the anterior abdominal wall in the operative intervention region were analyzed. There were examined 31 patients, suffering obesity stages I-III, their body mass index was (39.11 +/- 0.79) kg/m2 at average. Microcirculation disorders in soft tissues of the anterior abdominal wall have caused worsening of the postoperative period course in the patients. LDF is a highly informative noninvasive method, which have to be used trustworthy for estimation of a microcirculation bed state in the patients, suffering obesity.

[Immunomodulating effect of cyclophosphane under different modes of administration to mice]. / Immunomoduliruiushchee vliianie tsiklofosfana pri razlichnykh skhemakh vvedeniia ego mysham.

A study was made of the effect of injection of cyclophosphamide (CP) immunomodulating to BALB/c mice, according to 3 schemes of injection with the whole dose being 200 mg/kg. In all, the state of peripheral blood and spleen, the cellular content of lymph nodes and the number of DNA-synthesizing cells in them were studied, in addition to the ability of lymph node lymphocytes to proliferative reaction on T and B cells mitogens in vivo. It was determined that a 2-fold injection of CP, in contrast to 10- and 5-fold injections, resulted in splenomegaly and leukocytosis in the experimental animals. By means of quantitative tests in vivo, in was demonstrated that the dynamics of restoration of proliferative responses to mitogens depends on the CP injection scheme. These tests proved to be more informative for registration of immunomodulating effect of CP, than the study of cellular content of lymph nodes and the number of DNA-synthesizing cells in them.

[Immunomodulating effect of cyclophosphamide in experimental chemotherapy of transplanted tumors]. / Immunomoduliruiushchee deistvie tsiklofosfana pri eksperimental'noi khimioterapii perevivnykh opukholei.

A comparative morphofunctional analysis of lymphoid cells of BALB/c mice with the transplantable tumours was performed after the cyclophosphamide (CP) treatment. CP was injected by 3 schemes in a dose of 200 mg/kg of body weight. It was found that the more effective therapeutic scheme of CP treatment is accompanied by essential normalization of the ratio of lymphocyte populations in the lymph nodes against a background of a comparatively good state of proliferating cells as well as by a higher rate of restoration of proliferative responses to T and B cell mitogens in vivo.