[Cardiohemodynamic features and character of depressive disorders in patients with anemia varying grades of severity with chronic heart failure and chronic kidney disease].

Anemia and renal dysfunction are considered as predictors of an unfavorable course of chronic heart failure, the presence of depressive disorders in these patients is a risk factor for recurrent hospitalizations and deaths. The aim--study of morphological and functional changes in the myocardium, as well as the assessment of the existence and character of depressive disorders in patients with anemia varying grades of severity, developed on a background of chronic heart failure and chronic kidney disease. Structural and functional parameters of myocardium were investigated by echocardioscopy. Beck Depression Inventory was used to assess the presence and character of depressive disorders. The progression of anemic syndrome was accompanied by dilation of the left and right cavities of heart, inotropic function decreasing. In patients with anemic syndrome on a base of chronic heart failure and chronic kidney disease depressive disorders are observed mainly due to the cognitive-affective disorders in 1st grade anemia, and their combination with somatic manifestations of depression in patients with anemia of 2d and 3d grade.

[Pathogenetic mechanisms of the development of cardiac rhythm disorders in the acute period of myocardial infarction]. / Patogeneticheskie mekhanizmy razvitiia narushenii ritma serdtsa v ostrom periode infarkta miokarda.

The clinical course and biochemical, radioimmune and electrophysiologic findings were assessed in 421 patients with acute myocardial infarction involving heart rhythm and conductivity disorders and 49 patients with acute myocardial infarction, free of cardiac electrical instability. The studies were carried out during arrhythmias and after they were controlled, prior to treatment, at the peak of antiarrhythmic effect of medication, and after a continuous treatment course. Heart rhythm disorders related to acute myocardial infarction were accompanied with a marked response on the part of blood free fatty acids, sympatho-adrenal and kallikrein-kinin activity and carboxycathepsin. Metabolic and neurohumoral changes were eventually reversed and tended to normalize as soon as the sinus rhythm was restored by treatment.