[A rapid method of evaluation of the effectiveness of antibacterial drugs]. / Uskorennyi metod otsenki éffektivnosti antibakterial'nykh lekarstvennykh preparatov.

Efficacy of antibiotics in the treatment of experimental tularemia was studied comparatively on various biological models. It was shown that the antibiotics which proved active against the tularemia microbe in albino mice when studied by the rapid and routine methods were highly efficient in the treatment and prevention of experimental tularemia in rabbits and baboons (hamadryas). The experiments showed basic possibilities to perform rapid estimation (for at least 2 days) of drug efficacy in experimental glanders and melioidosis in golden hamsters. The rapid method developed by the authors was recommended for the use in primary estimation of the efficacy of new drugs in the treatment of tularemia, glanders and melioidosis.

[Sensitivity spectrum of Francisella tularensis to antibiotics and synthetic antibacterial drugs]. / Spektr chuvstvite'lnosti Francisella tularensis k antibiotikam i sinteticheskim antibakteria'lnym preparatam.

Sensitivity of 6 F. tularensis strains to 57 antibiotics and synthetic antibacterial drugs was studied. It was shown that the strains were highly sensitive to aminoglycosides, tetracyclines, anzamycins, quinolones, chloramphenicol, nitrofurantoin, nitroxoline, novobiocin and fusidin and resistant to penicillins, cephalosporins, polypeptides, vancomycin and sulfanylamides. The interrace differences in F. tularensis could be detected only by sensitivity to erythromycin, oleandomycin and spiramycin. There was observed no cross resistance to streptomycin and other aminoglycosides in F. tularensis. Assay of F. tularensis sensitivity to antibacterial drugs of various groups with the rapid photometric procedure and the agar diffusion method revealed that the results were highly comparable.

[Preparation and study of the anthrax protective antigen. II. Development of test preparations for the assessment of the quality of anthrax chemical vaccines and of the antigens obtained at various stages of its preparation]. / Poluchenie i izuchenie sibireiazvennogo protektivnogo antigens. Soobshchenie II. Test-preparaty dlia otsenki kachestva sibireiazvennoi khimicheskoi vaktsiny i antigenov, poluchaemykh na stadiiakh ee prigotovleniia

A homogeneous anthrax protective antigen (from the ST-I strain) characterized by a high immunogenicity and stability was obtained. Hyperimmune, monospecific to this preparation antiserum was prepared. It is suggested that these preparations can be used for the assessment of the quality of the anthrax chemical vaccine and of the antigens obtained at various stages of its preparation.

[Preparation and comparative evaluation of experimental anthrax diagnostic sera in experiments on animals]. / Poluchenie i sravnitel'naia otsenka éksperimental'nykh sibireiazvennykh diagnosticheskikh syvorotok v opytakh na razlichnykh zhivotnykh

The authors present the results of studies on obtaining and comparative assessment of experimental anthrax diagnostic sera in experiments on various animals. Donkeys, sheep, horses, rabbits and monkeys (Papio hamadryas) were immunized with the STI-I vaccine by a single scheme. The activity of the obtained sera was tested in the diffuse precipitation reaction by the amount of the detected antibodies and the titre. The most active sera were obtained from donkeys and sheep: their titre was 5.5 and 4 times greater and amount of the detected antibodies 2.6--2 times greater than in the sera of horses used up to the present time as producers of diagnostic anthrax preparations. The least active sera were obtained from monkeys.