ABSTRACT
Finoptin in a dose of 0,145 mg/kg prevented cardiomyocytic immune disorders in dogs and rats with cardiogenic shock of immune genesis. In test systems, the drug and nifedipine reduced the immune lysis in the cells by the complement.
Subject(s)
Calcium Channel Blockers/therapeutic use , Heart/drug effects , Immune System Diseases/prevention & control , Shock, Cardiogenic/prevention & control , Animals , Complement System Proteins/analysis , Complement System Proteins/drug effects , Disease Models, Animal , Dogs , Drug Evaluation, Preclinical , Female , Hemodynamics/drug effects , Immune System Diseases/etiology , Immune System Diseases/immunology , Immune System Diseases/physiopathology , Male , Rats , Shock, Cardiogenic/etiology , Shock, Cardiogenic/immunology , Shock, Cardiogenic/physiopathology , Time FactorsABSTRACT
The colony formation in spleen of lethally irradiated syngeneic or hybrid recipients was studied after transplantation of bone marrow cells, with or without macrophages from lymph nodules or from peritoneal cavity of mice, cells of macrophage-like cell line J-774, and monocytes from peripheral blood of healthy donors. The direction of stem cell differentiations in the presence of all the types of mononuclear phagocytes was seen to change from mainly erythroid to mainly myeloid one. The ratio of erythroid to myeloid colonies became equal to 0.5-0.9 instead of 2.0, when bone marrow cells were injected with equivalent quantity of mononuclear phagocytes. This new regulatory function of mononuclear phagocytes is discussed.
