[Blood plasma amino acids and total protein, their elimination and catabolism during the hemofiltration of patients with acute kidney failure]. / Aminokisloty i obshchii belok plazmy krovi, vydelenie i katabolizm ikh pri gemofil'tratsii u bol'nykh s ostroi pochechnoi nedostatochnost'iu.

Intermittent hemofiltration (HF) was applied to the treatment of 8 patients (3 men and 5 women) with the grave pattern of acute renal failure (ARF) of prerenal origin. Altogether 23 sessions (from one to six in every patient) were performed with replacement of 44.3 +/- 2.8 1 liquid on the average. Two patients died. Of these, one female patient died from progressive peritonitis and sepsis and the other one from cisplatinum intoxication, bone marrow aplasia and sepsis. The content of blood plasma amino acids (AA), total protein and its fractions was measured before and after HF. Measurements were also made of excretion of those substances with filtrate. Besides, the amount of protein AA catabolized during the procedure was calculated according to the kinetics of urea. The authors hold that ARF-associated changes in the content of AA are primarily determined by adaptive shifts in metabolism. Differences in AA consumption were revealed to depend on the period and quality of adaptation. On the average HF brought about losses of 7.5 g AA and 73.1 g protein with filtrate. At the same time 37.5 g AA underwent oxidation, while urea generation rose 2-fold, amounting to 0.48 mmol/kg bw per hour. It is concluded that in ARF patients undergoing intermittent HF, it is necessary that anabolizing glucose and insulin therapy be applied together with replacement infusion of AA and (or) protein.

[Importance of amino acid mixtures in the supplementary nutrition of patients with chronic diseases of the small intestine]. / Znachenie aminokislotnykh smesei v dopolnitel'nom pitanii bol'nykh s khronicheskimi zabolevaniiami tonkoi kishki.

The clinical effectiveness of alvesin, a mixture of pure amino acids, balanced by the amino acid composition, was studied in the treatment of patients with chronic diseases of the small intestine. The drug was well tolerated by the patients after its parenteral administration. A high clinical effect of alvesin was recorded in 98 patients suffering from chronic enteritis, celiac disease, general variable immunodeficiency. The optimal dose of the drug was determined.

[Protein metabolism in obesity patients]. / Sostoianie belkovogo obmena u bol'nykh ozhireniem.

Protein metabolism was studied in patients with alimentary obesity. It was found that the reduction of excessive body weight under the action of a complex of measures, including dietetics, exercise therapy and physiotherapy, induced positive shifts in the amino acid spectrum of blood. The blood serum creatinine content and urinary excretion of creatinine and creatine remained unchanged. The nitrogenous balance was maintained even in cases of highly restricted diets.

[Absorption of essential amino acids in patients with chronic enteritis]. / Vsasyvanie nezamenimykh aminokislot u bol'nykh khronicheskim énteritom

Continuous perfusion was applied in studying the absorption of essential amino acids in the duodenum and the proximal part of the jejunum in healthy persons and in patients with chronic enteritis of the land ii degrees of severity. All the patients demonstrated a reduced rate of absorption. The degree of the absorption derangement increased parallel with the severity of the affection. In the duodenum the absorption proceeded slower than in the upper portion of the jejunum.