ABSTRACT
Complex examination of hemostatic system and T-cell-mediated immunity in 19 cases of stage II-IV lung cancer showed an increased activity of blood coagulation system to be associated with a decrease in OKT3+, OKT11+ and OKT4+ T-lymphocyte subsets levels. A reverse correlation was established between plasma--Willebrand's factor level and those of OKTè+ and OKT8+ lymphocytes whereas a direct one--between blood-platelet aggregate level and that of OKT4+. The data obtained emphasized the need to consider the status of hemostatic system when evaluating the function of cell-mediated immunity.
Subject(s)
Hemostasis/physiology , Lung Neoplasms/blood , T-Lymphocytes/immunology , Adult , Aged , Antibodies, Monoclonal , Antigens, Neoplasm/analysis , Antigens, Surface/analysis , Blood Coagulation Tests , Humans , Lung Neoplasms/immunology , Middle Aged , Postoperative PeriodABSTRACT
A total of 45 patients were given cytosar and daunorubicin therapy at small doses. Of them 23 patients were with acute nonlymphoblastic leukemia, 12--with hemopoietic dysplasia, and 10--with chronic myeloid leukemia. Cytosar was injected subcutaneously every 12 h at a dose of 10 mg/m2 for 10-25 days, daunorubicin was injected intravenously by drop infusion at a dose of 5 mg/m2. Clinicohematological remission was obtained in 13 patients, clinicohematological improvement in 16. Thus, a positive effect was achieved in 29 patients (64%). The authors provided some data on the influence of small doses of cytosar and daunorubicin on cell maturation in vitro.
Subject(s)
Cytarabine/administration & dosage , Leukemia, Myeloid, Acute/drug therapy , Leukemia, Myeloid/drug therapy , Adolescent , Adult , Aged , Antineoplastic Combined Chemotherapy Protocols , Child , Child, Preschool , Daunorubicin/administration & dosage , Drug Evaluation , Female , Humans , Injections, Intravenous , Injections, Subcutaneous , Male , Middle Aged , Remission InductionABSTRACT
The authors describe the results of the cloning of hemopoietic cells from 85 patients with different patterns of nonlymphoblastic leukemias in the agar drop--liquid medium system. It is shown that measurement of the colony-stimulating activity of hemopoietic cells and their growth pattern as well as morphological study of the cultures can be employed in practical hematology for making diagnosis and differential diagnosis, for evaluation of the treatment efficacy and prediction of the disease prognosis. The presence of blast colonies, an increase in the number of cell aggregations is regarded as an unfavourable prognostic criterion. Elevation of the colony-stimulating activity of hemopoietic cells is evidence of a more favourable prognosis.
