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5.
Appl Microbiol ; 23(1): 72-7, 1972 Jan.
Article in English | MEDLINE | ID: mdl-5059623

ABSTRACT

A process is described for the microbial degradation of cholesterol and plant sterols, to produce androsta-1, 4-diene-3, 17-dione and androst-4-ene-3, 17-dione, by two newly isolated bacteria designated Mycobacterium sp. NRRL B-3683 and Mycobacterium sp. NRRL B-3805. These myocbacteria produce substantial amounts of 17-ketonic compounds without appreciable degradation of the steroid nucleus. No ring degradation inhibitory agents are necessary. The first microbiological production of 20alpha-hydroxymethylpregna-1, 4-dien-3-one is also reported.


Subject(s)
Mycobacterium/metabolism , Sterols/metabolism , Androstanes/biosynthesis , Biodegradation, Environmental , Chemical Phenomena , Chemistry , Cholesterol/metabolism , Chromatography, Gas , Chromatography, Thin Layer , Culture Media , Fermentation , Mycobacterium/growth & development , Mycobacterium/isolation & purification , Mycobacterium/radiation effects , Plants , Pregnanes/biosynthesis , Radiation Effects , Ultraviolet Rays
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