[Lightmicroscopic studies of plasma permeability at the blood brain barrier in experimental neurogenic interoreceptive hypertension of the rat (author's transl)]. / Lichtmikroskopische Studien der Plasmapermeabilität an der Blut-Hirnschranke bei der experimentellen neurogen interorezeptiven Hypertonie der Ratte.

The plasma permeation with its consequences on the nervous system was studied by means of an experimental neurogenic interoreceptive hypertension model. Out of 30 experimental animals (5 controls) showed 7 cerebral extravasations with blood pressure value ranging from 160--170 mm Hg within 4 and 8 weeks, respectively, as proved by Evans Blue injection or subsequent staining of the plasma with Luxol Fast Blue. The permeation sites were found hood-shaped on arterioles with a diameter of 15--30 micrometers, in multifocal arrangement with a certain preference for the frontal cerebral structures. The cerebral damages proved to be microinfarctions, mostly incompletely anemic necroses and forms of neuronal degeneration. Topical coincidence with extravasations is not always present. Further causal factors of cerebral lesions are discussed.

[Changes of activity of alkaline phosphatase at the circulatory system in experimental hypertension of the rat (author's transl)]. / Aktivitätsschwankungen der alkalischen Phosphatase am Gefässsystem bei der experimentellen Hypertonie der Ratte

Changes of activity of the alkaline phosphatase are investigated in the border of the outer media of vessels in two different models of hypertension (Goldblatt and Carotis-Sinus) in the rat. After onset of hypertension an increase of activity takes place in an area largely overlapping a necrosis of the outer medial region of the aorta. The formation of regenerated tissue leads to a thickening of the adventitia and to a decrease of the activities. Changes of the activities in the peripheral vessels presumably are due to participation of other factors. Indications to this effect are discussed.